Jag2 Gene Summary [Mouse]
Enables Notch binding activity. Involved in auditory receptor cell fate commitment; gamma-delta T cell differentiation; and positive regulation of Notch signaling pathway. Acts upstream of or within several processes, including epithelial cell apoptotic process involved in palatal shelf morphogenesis; odontogenesis of dentin-containing tooth; and respiratory system process. Located in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and surface ectoderm. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy. Orthologous to human JAG2 (jagged canonical Notch ligand 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Jag2 |
| Official Name | jagged 2 [Source:MGI Symbol;Acc:MGI:1098270] |
| Ensembl ID | ENSMUSG00000002799 |
| Bio databases IDs | |
| Aliases | jagged 2 |
| Synonyms | D12Ggc2e, HJ2, JAGGED 2, jagged canonical Notch ligand 2, LGMDR27, mJagged2-1, SER2, Serh, Serrate2, sm |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Jag2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- von Willebrand factor type C domain
- N terminus of Notch ligand C2-like domain
- Human growth factor-like EGF
- protein binding
- growth factor
- EGF repeat
- notch binding
- Delta serrate ligand
- EGF_CA
Pathways
Biological processes and signaling networks where the Jag2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- cyanosis
- tinnitus
- autosomal recessive limb-girdle muscular dystrophy type 27
- cleft palate
- syndactyly
- serous ovarian cancer
- primary biliary cirrhosis
- limb-girdle muscular dystrophy type 2
phenotypes
- preweaning lethality complete penetrance
- abnormal apical ectodermal ridge morphology
- abnormal autopod morphology
- abnormal caudal vertebrae morphology
- abnormal cochlear outer hair cell morphology
- abnormal digit development
- abnormal embryonic autopod plate morphology
- abnormal gamma-delta T cell differentiation
- abnormal limb bud morphology
- abnormal orientation of cochlear hair cell stereociliary bundles
- abnormal orientation of inner hair cell stereociliary bundles
- abnormal phalanx morphology
- abnormal tail morphology
- abnormal thymus medulla morphology
- abnormal thymus morphology
- absent maxillary shelf
- absent palatine bone horizontal plate
- cleft palate
- cleft secondary palate
- cyanosis
- decreased gamma-delta T cell number
- decreased organ of Corti supporting cell number
- epidermal hyperplasia
- failure of palatal shelf elevation
- female infertility
- fused phalanges
- fused tarsal bones
- increased cochlear hair cell number
- increased cochlear inner hair cell number
- increased cochlear outer hair cell number
- kinked tail
- neonatal lethality complete penetrance
- palatal shelf fusion with tongue or mandible
- parakeratosis
- perinatal lethality complete penetrance
- perinatal lethality incomplete penetrance
- postnatal lethality complete penetrance
- postnatal lethality incomplete penetrance
- respiratory distress
- syndactyly
- thick apical ectodermal ridge
role in cell
- expression in
- number
- quantity
- differentiation
- proliferation
- survival
- apoptosis
- development
- orientation
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- perinuclear region
- cellular membrane
- Nucleus
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Jag2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatogenesis
- odontogenesis of dentin-containing tooth
- auditory receptor cell fate commitment
- positive regulation of Notch signaling pathway
- regulation of cell proliferation
- respiratory system process
- T cell differentiation
- thymic T cell selection
- skeletal system development
- Notch signaling pathway
- in utero embryonic development
- gamma-delta T cell differentiation
- cell differentiation
- morphogenesis of embryonic epithelium
- regulation of cell adhesion
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- calcium ion binding
- Notch binding