Birc3 Gene Summary [Mouse]
Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process and ubiquitin protein ligase activity. Involved in necroptotic process; negative regulation of metabolic process; and negative regulation of necroptotic process. Acts upstream of or within cellular response to tumor necrosis factor; positive regulation of protein polyubiquitination; and regulation of non-canonical NF-kappaB signal transduction. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system and genitourinary system. Human ortholog(s) of this gene implicated in colorectal carcinoma; esophagus adenocarcinoma; extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue; hepatocellular carcinoma; and lung non-small cell carcinoma. Orthologous to human BIRC3 (baculoviral IAP repeat containing 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Birc3 |
| Official Name | baculoviral IAP repeat-containing 3 [Source:MGI Symbol;Acc:MGI:1197007] |
| Ensembl ID | ENSMUSG00000032000 |
| Bio databases IDs | |
| Aliases | baculoviral IAP repeat-containing 3 |
| Synonyms | Api2, baculoviral IAP repeat-containing 3, cIAP-1, cIAP2, Iap2, Miap2, MIHC, RNF49 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Birc3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- enzyme
- Ring finger domain
- protein binding
- Caspase recruitment domain
- binding protein
- BIR
- transferase
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- Death Domain Superfamily of protein-protein interaction domains
- Zinc finger, C3HC4 type (RING finger)
Pathways
Biological processes and signaling networks where the Birc3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Amyotrophic Lateral Sclerosis Signaling
- Apoptosis Signaling
- Death Receptor Signaling
- Erythropoietin Signaling
- Induction of Apoptosis by HIV1
- Molecular Mechanisms of Cancer
- Neuroinflammation Signaling Pathway
- Protein Ubiquitination Pathway
- RANK Signaling in Osteoclasts
- Role of JAK2 in Hormone-like Cytokine Signaling
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- TNFR1 Signaling
- TNFR2 Signaling
- TWEAK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- endotoxin shock response
- sepsis
- hemopericardium
- Marfan syndrome
- bleeding
- peritonitis
- granulocytosis
- congestive heart failure
role in cell
- activation in
- proliferation
- apoptosis
- phosphorylation in
- cell death
- degradation in
- molecular cleavage in
- production in
- quantity
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm