Target List
Covers all exons in all known transcripts of targeted genes based on the Human GRCh38 genome build
Brain Cancers
Anaplastic Glial Tumors
CDKN2A (P16INK4A)CDKN2B (p15INK4b)MDM2PTENRB1TP53 (p53)
Astrocytomas
ATRXBRAFCHEK2 (RAD53)FGFR1IDH1IDH2KRASNOTCH1PTPN11RB1TP53 (p53)
Ependymomas
CDKN2A (P16INK4A)CDKN2B (p15INK4b)H3-3ANF2NOTCH1
Glioblastomas
ALKAPCBCORBRAFCDK4CDK6CDKN2A (P16INK4A)CDKN2B (p15INK4b)CREBBP (CBP)EGFR (ERBB1)ERBB2 (HER-2, NEU)FGFR3H3-3AH3C2IDH1IDH2KIT (CD117)MDM2METMLH1MSH2MTORMYCNOTCH1NRASPIK3CA (p110-alpha)PMS2PTENRB1STK11 (LKB1)TERTTP53 (p53)
Gliomas
ACVR1 (ALK2)BRCA2CHEK2 (RAD53)FGFR1H3-3APDGFRAPIK3CA (p110-alpha)PTENTP53 (p53)
High-Grade Gliomas
ATRXBRAFCICEGFR (ERBB1)FUBP1IDH1IDH2
Medulloblastomas
BRCA2CDK4CREBBP (CBP)CTNNB1FGFR1GLI2IDH1IDH2MSH2MYCMYCNNRASPIK3CA (p110-alpha)PTCH2SMARCA4SMARCB1SUFUTP53 (p53)
Meningiomas
CDKN2A (P16INK4A)CDKN2B (p15INK4b)NF2PTEN
Oligodendrogliomas
IDH1IDH2MSH2NOTCH1TERT
Breast Cancers
Carcinomas
ATMBARD1BRCA1BRCA2BRIP1CDK12CDK4CHEK1CHEK2 (RAD53)EGFR (ERBB1)ERBB2 (HER-2, NEU)ESR1 (ERα)FANCLKIT (CD117)KRASMETMLH1MLH3MSH2MSH3MSH6PALB2PDGFRAPIK3CA (p110-alpha)PMS1PMS2RAD51BRAD51CRAD51DRAD54L
Ductal Carcinomas
ARCCND1CDH1 (E-Cadherin)CYP2D6FANCD2FBXW7FGFR1FGFR2MRE11MYCNBNNTRK3PPM1DPPP2R1ARB1CC1SF3B1SLC22A18STK11 (LKB1)TP53 (p53)
ER-Positive Carcinomas
CDH1 (E-Cadherin)RB1CC1SF3B1
HER-Positive Carcinomas
ARCCND1FANCD2NTRK3PPM1DRB1CC1
Metastatic Breast Cancers
AKT1BRCA1BRCA2ERBB2 (HER-2, NEU)ERBB3ESR1 (ERα)MDM2NF1PALB2PIK3CA (p110-alpha)PTEN
Mismatch Repair (MMR) Genes
MLH1MSH2MSH6PMS2
Colorectal Cancers
Adenocarcinomas
APCARID1AATMAXIN2BARD1BAXBMPR1A (ALK3)BRAFBRCA1BRCA2BRIP1BUB1BUB1BCDK12CDKN2A (P16INK4A)CHEK1CHEK2 (RAD53)CTNNB1DCCDLC1EGFR (ERBB1)EP300ERBB2 (HER-2, NEU)ERBB3ESR1 (ERα)FANCLFBXW7FGFR1FGFR3FLCNGNASHRASKIT (CD117)KRASMAP2K1MCCMETMLH1MLH3MSH2MSH3MSH6MUTYHMYCNRASPALB2PDGFRAPDGFRLPMS1PMS2POLD1POLEPTENPTPN12PTPRJRAD51BRAD51CRAD51DRAD54BRAD54LRETRNF43SMAD4 (MADH4)SOX9SRCSTK11 (LKB1)TCF7L2TGFBR2TP53 (p53)
Metastatic Colorectal Cancers
AKT1ATMBRAFERBB2 (HER-2, NEU)KRASMETNRASPIK3CA (p110-alpha)
Mismatch Repair (MMR) Genes
EPCAMMLH1MSH2MSH6PMS2
Other Colorectal Cancer Genes
DPYDERCC1TYMSUGT1A1
Lung Cancers
Adenocarcinomas
ABL1AKT1ALKATMBRAFCCND1CD274 (PD-L1)CD274 (PD-L1)CDK4CDKN2A (P16INK4A)CTNNB1DDR2EGFR (ERBB1)ERBB2 (HER-2, NEU)FGFR1FGFR3HRASKRASMAP2K1MAP3K8METMYCMYCNNRASNTRK1PIK3CA (p110-alpha)PPP2R1BPRKNPTENRETROS1SLC22A18STK11 (LKB1)TP53 (p53)TSC2
Malignant Pleural Mesotheliomas
BAP1NF2
Non-Small Cell Lung Cancers (NSCLC)
AKT1ALKATMBARD1BRAFBRCA1BRCA2BRIP1CCND1CDK12CDK4CDKN2A (P16INK4A)CHEK1CHEK2 (RAD53)CTNNB1EGFR (ERBB1)ERBB2 (HER-2, NEU)FANCLFGFR3HRASIDH1IRF1KIT (CD117)KRASMAP2K1METMLH1MLH3MSH2MSH3MSH6MYCNRASPALB2PDGFRAPIK3CA (p110-alpha)PMS1PMS2PTENRAD51BRAD51CRAD51DRAD54LRETROS1TP53 (p53)
Small Cell Lung Cancers (SCLC)
CD274 (PD-L1)CD274 (PD-L1)HRASMYCMYCNNTRK1PIK3CA (p110-alpha)PPP2R1BPTENRB1TP53 (p53)
Squamous Cell Carcinomas
BRAFCD274 (PD-L1)CD274 (PD-L1)CDKN2A (P16INK4A)DDR2EGFR (ERBB1)FGFR1FGFR3HRASMAP3K8MYCMYCNNTRK1PIK3CA (p110-alpha)PPP2R1BPTENSLC22A18TP53 (p53)TSC2
Myeloid Neoplasms
Acute Lymphoblastic Leukemia (ALL)
ABL1ABL2 (ARG)BIRC3 (c-IAP2)BRAFBTKCDKN2A (P16INK4A)CDKN2B (p15INK4b)CREBBP (CBP)CRLF2 (TSLPR)EBF1EP300ETV6FBXW7FLT3GATA3HRASIKZF1IL7RJAK1JAK2JAK3KDM6AKMT2AKRASMYCNOTCH1NRASPAX5PDGFRBPLCG2PTENPTPN11RUNX1 (AML1)SF3B1SH2B3TP53 (p53)
Acute Myeloid Leukemia (AML)
ANKRD26ASXL1ATRXBRCA1BRCA2CBFBCBLBCBLCCCND2CDC25CCEBPACUX1DCKDDX41DHX15DNMT3AELANEETV6FLT3GATA1GATA2GNASHRASIDH1IDH2IKZF1IKZF2IKZF3JAK2KDM6AKIT (CD117)KMT2AKRASLUC7L2MTORNPM1NRASNUP214PDGFRAPICALMPRPF8PTPN11RB1RBBP6RPS14RUNX1 (AML1)SF3B1SLC29A1SMC1ATERTTET1TET2TP53 (p53)U2AF1U2AF2WT1ZEB2
Acute Promyelocytic Leukemia (APML; APL)
CEBPANPM1NUMA1RARARUNX1 (AML1)
Atypical Chronic Myeloid Leukemia (aCML)
ASXL1CBLCEBPAEZH2FLT3JAK2KRASNPM1NRASRUNX1 (AML1)SETBP1SRSF2TET2U2AF1
Chronic Lymphocytic Leukemia (CLL)
ATRXBCL2BIRC3 (c-IAP2)BRAFCBLBCCND2CD38CUX1GNASGNB1LUC7L2MYD88NOTCH1NRASPTPN11SF3B1TP53 (p53)U2AF2XPO1ZAP70
Chronic Myeloid Leukemia (CML)
ABL1ASXL1BCORBCRBRAFCBLCREBBP (CBP)DNMT3ADNMT3BEZH2IDH1IDH2IKZF1JAK2KRASNPM1NRASRUNX1 (AML1)TET1TET2TP53 (p53)WT1
Chronic Myelomonocytic Leukemia (CMML)
ASXL1BCORBCORL1CBLCEBPADNMT3AEZH2FLT3IDH1IDH2JAK2KIT (CD117)KRASMPLNF1NPM1NRASPHF6PTPN11RUNX1 (AML1)SETBP1SF3B1SRSF2STAG2TET2TP53 (p53)U2AF1ZRSR2
Hairy Cell Leukemia
BRAFCDKN1B (P27KIP1)MAP2K1TP53 (p53)
Juvenile Myelomonocytic Leukemia
ARHGAP26CBLKRASNRASPTPN11
Acute Lymphocytic Lymphomas
BIRC3 (c-IAP2)BTKCDKN2A (P16INK4A)CDKN2B (p15INK4b)MYCNOTCH1PLCG2SF3B1TP53 (p53)
B Cell Lymphomas
BCL6BRAFCD79ACHEK2 (RAD53)EZH2MAP2K1MYD88STAT6TNFRSF14TP53 (p53)
Burkitt Lymphomas
CBLBGNA13H1-4MTORMYC
Diffuse Large B Cell Lymphomas
B2MBCL2CBLBGNA13H1-4KMT2DMTORPIM1PRPF8SOCS1TNFAIP3
Follicular Lymphomas
ARID1ABCL10BCL2CARD11CREBBP (CBP)EP300EZH2FOXO1KMT2DMEF2B
Mantle Cell Lymphomas
ATMCCND1
Marginal Zone Lymphomas
KLF2MYD88NOTCH2TNFAIP3TP53 (p53)
Mucosa-Associated Lymphoid Tissue (MALT) Lymphomas
BCL10TNFAIP3
Non-Hodgkin Lymphomas
BRAFCASP10 (MCH4)NRASPIK3CA (p110-alpha)RAD54BRAD54LTP53 (p53)
Primary Cutaneous Lymphomas
CD79BMYD88
Small Lymphocytic Lymphomas
ATRXBCL2CBLBCCND2CUX1GNASLUC7L2U2AF2XPO1
T Cell Lymphomas
ARID1BATMCBLBCCR4DNMT3AIDH1IDH2INO80JAK1JAK3RHOASETD2STAT3STAT5BTET2
Myelodysplastic Syndromes
ANKRD26ASXL1ATRXBCORBCORL1CALRCBLCEBPACSF3R (GM-CSFR)CUX1DDX41DKC1DNMT3AETNK1ETV6EZH2FLT3GATA2GNASGNB1IDH1IDH2JAK2JAK3KIT (CD117)KRASMPLNF1NPM1NRASPHF6PIGAPPM1DPTPN11RAD21RUNX1 (AML1)SAMD9SAMD9LSETBP1SF3B1SMC3SRP72SRSF2STAG2STAT3TERCTERTTET2TP53 (p53)U2AF1WT1ZRSR2
Myeloproliferative Neoplasms
ASXL1BCORCALRCBLCSF3R (GM-CSFR)DNMT3AETV6EZH2IDH1IDH2JAK2KIT (CD117)MPLNOTCH1NRASPDGFRARUNX1 (AML1)SETBP1SF3B1SH2B3SRSF2STAT3STAT5BTET2TP53 (p53)U2AF1ZRSR2
Essential Thrombocythemia
ASXL1CBLIDH2JAK2MPLSF3B1TET2TP53 (p53)
Multiple Myeloma
ATMBARD1BRAFBRCA1BRCA2BRIP1CHEK1CHEK2 (RAD53)CXCR4EGFR (ERBB1)ERBB2 (HER-2, NEU)FANCLFGFR3IDH1IDH2KIT (CD117)KRASMETNRASPALB2PDGFRARAD51BRAD51CRAD51DRETTP53 (p53)
Plasma Cell Myeloma
HRASMTORRB1SLC29A1
Polycythemia Vera
ASXL1DNMT3AEZH2IDH1JAK2NRASTET2TP53 (p53)
Primary Myelofibrosis
ASXL1CBLDNMT3AEZH2IDH1IDH2JAK2MPLNF1NRASSETBP1SF3B1SRSF2TET2TP53 (p53)
Systemic Mastocytosis
ASXL1CBLDNMT3AETV6EZH2IDH2JAK2KIT (CD117)KRASNPM1NRASRUNX1 (AML1)SETBP1SF3B1SRSF2TET2TPSAB1U2AF1
Waldenstrom Macroglobulinemia
CXCR4MYD88
Ovarian Cancers
Endometrioid Carcinomas
CDKN2A (P16INK4A)CTNNB1FANCFPOLEPPP2R1A
Epithelial Carcinomas
ABRAXAS1ARID1AATMBARD1BRAFBRCA1BRCA2BRIP1CCNE1CDK12CHEK1CHEK2 (RAD53)ERBB2 (HER-2, NEU)ERCC1KRASMRE11NBNNF1PALB2PIK3CA (p110-alpha)PTENRAD51BRAD51CRAD51DRB1TP53 (p53)WT1
Granulosa Cell Tumors
AKT1FOXL2
Mixed Adenosquamous Carcinomas
AKT1ATRATRXBLMCCND1CCND2CCNE1CDH1 (E-Cadherin)DICER1ERBB3FANCAFANCCFANCD2FANCEFANCFFANCIFANCLFANCMFBXW7FGFR1FGFR2FGFR3KIT (CD117)MYCOPCML (OBCAM)PDGFRAPIK3R1 (p85-ALPHA)POLEPRKNRAD50RAD51RAD52RAD54LRB1RPA1SMARCA4STK11 (LKB1)
Mucinous Carcinomas
ATRXCDKN2A (P16INK4A)ERBB3PDGFRA
Serous Carcinomas
ATRATRXBLMCCND1CCND2CCNE1CDH1 (E-Cadherin)CDKN2A (P16INK4A)DICER1ERBB3FANCAFANCCFANCD2FANCEFANCFFANCGFANCIFANCLFANCMFBXW7FGFR1FGFR2FGFR3KIT (CD117)MYCPPP2R1ARAD50RAD51RAD52RAD54LRB1RPA1SMARCA4
Mismatch Repair (MMR) Genes
MLH1MSH2MSH6PMS2
Pancreatic Cancers
Adenocarcinomas
ATMCDKN2A (P16INK4A)CFTRFANCCFANCGMLH1MSH2MSH6PALB2PALLDPMS2PRSS1SMAD4 (MADH4)SPINK1STK11 (LKB1)TP53 (p53)
Advanced Ductal Adenocarcinomas
BRAFBRCA1BRCA2ERBB2 (HER-2, NEU)KRASMDM2PIK3CA (p110-alpha)
Ductal Carcinomas
APCARID1ACDK6CTNNB1ERBB3FBXW7FGFR1GNASKDM6AKRASMETMYCNRASPIK3R3POLEPREX2PTCH1PTENRNF43ROBO2SLC29A1SOX9TCF7L2
Mismatch Repair (MMR) Genes
MLH1MSH2MSH6PMS2
Prostate Cancers
Adenocarcinomas
ABRAXAS1APCARATRBARD1BRAFBRIP1CDK12CHEK1CHEK2 (RAD53)EPHB2ERGETV1ETV4ETV5FANCAFANCLFGFR1FOXA1GEN1HRASIDH1KDM6AKLF6KMT2DKRASMAD1L1MED12MRE11MXI1MYCNBNPIK3R1 (p85-ALPHA)PPP2R2APTENRAD51BRAD51CRAD51DRAD54LRAF1RB1SPOPTP53 (p53)ZFHX3
Advanced Prostate Cancers
AKT1ATMBRCA1BRCA2PALB2PIK3CA (p110-alpha)PTEN
Ductal Carcinomas
CTNNB1
Mismatch Repair (MMR) Genes
MLH1MSH2MSH6PMS2