Target List
Oncogenes & Tumor Suppressor Genes
Anapc10, Anapc11, Anapc4, Anapc5, Anapc7, Apc2, Bard1, Birc2 (c-IAP2), Birc3 (c-IAP1), Birc7, Brca1, Btrc (beta-TrCP1), Cbl, Cblb, Cblc, Cbll1, Cdc16, Cdc20, Cdc23, Cdc26, Cdc27, Cdh1 (E-cadherin), Cul9, Fbxo5, Fbxw5, Mdm2, Mdm4, Rchy1, Rnf139, Siah1, Siah2, Skp2, Traf2, Traf6, Traf7, Vhl, Xiap
HECT
Hace1, Hectd2, Hecw1, Hecw2, Herc2, Herc3, Herc4, Herc6, Itch, Nedd4, Nedd4l, Smurf1, Smurf2, Trip12, Ubr5, Wwp1
U-Box
Nosip, Prpf19, Stub1, Ube4a, Ubox5, Wdsub1
UBL
Pias1, Pias2, Pias3, Pias4, Rbx1, Topors, Uhrf1, Uhrf2
Single RING-Finger
BIRC/IAP
Birc2 (c-IAP2), Birc3 (c-IAP1), Birc7, Xiap
BRE1
Rnf20, Rnf40
CBL
Cbl, Cblb, Cblc, Cbll1
Deltex
Dtx2, Dtx4, Rnf146
Goliath
Rnf149, Rnf167, Znrf4
Makorin
Mkrn1, Mkrn2
Membrane-Associated Ring Finger Proteins
March2, March3, March5, March7, March8, March9, March10
MDM
Mdm2, Mdm4
Mindbomb Homologs
Mib2, Mib1
NFX
Nfx1, Nfxl1
PDZRN
Lnx1, Lnx2, Pdzrn4
Pellino
Peli1, Peli2, Peli3
PEX
Pex12, Pex2
Polycomb Group Genes
Bmi1 (Pcgf4), Pcgf1, Pcgf2, Pcgf3, Pcgf6, Ring1, Rnf2
Praja
Pja2, Rnf126, Rnf115
RBR
Arih1, Arih2, Cul9, Park2 (QuantiNova Symbol: AABR07001519.1), Rbck1, Rnf144b, Rnf19a, Rnf19b, Rnf216, Rnf31 (Irf9)
Seven in Absentia
Siah1, Siah2
SH3
Sh3rf1, Sh3rf2
TRAC-I
Rnf114, Rnf125, Rnf138 (QuantiNova Symbol: AABR07031480.1), Rnf166
TRAF
Traf2, Traf3, Traf4, Traf6, Traf7
TRIM / RBCC
Mid1, Pml, Rnf135 (Rhot1), Trim11, Trim13, Trim17, Trim2, Trim23, Trim25, Trim26, Trim27, Trim28, Trim3, Trim32, Trim36, Trim37, Trim39, Trim40, Trim41, Trim42, Trim44, Trim45, Trim46, Trim47, Trim5, Trim50, Trim54, Trim55, Trim63 (Murf1), Trim69, Trim72, Trim8, Trim9
UBR Box
Ubr3, Ubr2, Ubr4, Ubr7
VPS
Vps11, Vps18, Vps41
Other Single RING-Finger Proteins
Atrx, Bcor, Bfar, Brca1, Cbx8, Ccnb1ip1, Cdc34, Cgrrf1, Chfr, Cnot4, Fancl, Hltf, Irak1, Rnf220, Lrsam1, Malt1, Mnat1, Map3k1 (Mekk1), Mex3c, Mgrn1, Mul1, Mycbp2, Mylip, Neurl1 (Neu1), Neurl2, Nhlrc1, Ostm1, Pax6, Phf7, Phrf1, Irf2bpl, Rad18, Rag1, Rbbp6, Rc3h2, Rchy1, Arel1, Rlim (QuantiNova Symbol: NEWGENE_1559832), Rnf10, Rnf111, Rnf113a2, Rnf121, Rnf139, Rnf145, Rnf150, Rnf152, Rnf180, Rnf181, Rnf207, Rnf215, Rnf219, Rnf25, Rnf26, Rnf34, Rnf38, Rnf4, Rnf41, Rnf44, Rnf6, Rnf8, Rspry1, Sart1, Shprh, Syvn1, Topors, Traip, Ttc3, Uba52, Ubb, Ubc, Unk, Zfp91, Znrf2, Zswim2
Multi-Subunit RING-Finger
SCF Complex
Btrc (beta-TrCP1), Ccnf, Cul1, Fbxl12, Fbxl15, Fbxl17, Fbxl20, Fbxl3, Fbxl4, Fbxl5, Fbxl6, Fbxl7, Fbxo11, Fbxo17, Fbxo18, Fbxo2, Fbxo21, Fbxo22, Tspan17, Fbxo24, Fbxo25, Fbxo28, Fbxo30, Fbxo32, Fbxo33, Fbxo34, Fbxo38, Fbxo4, Fbxo42, Fbxo43, Fbxo46, Fbxo5, Fbxo6, Fbxo7, Fbxo9, Fbxw10, Fbxw11, Fbxw2, Fbxw4, Fbxw5, Fbxw8, Fbxw9, Foxl2, Kdm2a, Kdm2b, Lmo7, Rbx1, Fbxo27, Skp1, Skp2
ECV Complex
Cul2, Fem1b, Rbx1, Tceb1, Vhl
CUL3 Complex
Abtb1, Abtb2, Btbd1, Btbd16, Btbd3, Cul3, Diablo (Smac), Enc1, Gan, Gmcl1, Ipp, Klhl41, Kbtbd11, Kbtbd2, Kbtbd4, Kbtbd6, Kctd13, Keap1, Klhl10, Klhl12, Klhl13, Klhl17, Klhl2, Klhl20, Klhl21, Klhl22, Klhl24, Klhl7, Klhl9, Nacc2, Rbx1, Rhobtb1, Rhobtb2, Rhobtb3, Spop, Tnfaip1, Zbtb1, Zbtb11, Zbtb16, Zbtb17, Zbtb20, Zbtb38, Zbtb39, Zbtb43, Zbtb5, Zbtb7a
CUL4 Complex
Brwd1, Crbn, Cul4a, Cul4b, Dcaf10, Dcaf11, Dcaf7, Dcaf8, Dda1, Ddb1, Det1, Ercc8, Rbx1, Phip, Trpc4ap, Wdtc1
ECS Complex
Asb1, Asb11, Asb13, Asb18, Asb2, Asb3, Asb8, Cish, Cul5, Lrrc41, Rab40b, Rnf7, Socs1, Socs2, Socs3, Socs4, Socs5, Socs6, Spsb1, Spsb2, Spsb3, Spsb4, Tceb1, Wsb1, Wsb2
CUL7 Complex
Rbx1, Skp1
APC/C
Anapc10, Anapc11, Anapc2, Anapc4, Anapc5, Anapc7, Apc2, Cdc16, Cdc20, Cdc23, Cdc26, Cdc27, Cdh1 (E-cadherin)
BRCC Complex
Bard1, Brca1, Brca2, Brcc3, Bre, Rad51
Multi-Subunit RING-Finger Cullins & Adaptors
Anapc11, Apc2, Cul1, Cul2, Cul3, Cul4a, Cul4b, Cul5, Ddb1, Rbx1, Rnf7, Skp1, Tceb1