Eif2a Gene Summary [Mouse]
Predicted to enable RNA binding activity; ribosome binding activity; and translation initiation factor activity. Acts upstream of or within several processes, including SREBP signaling pathway; protein phosphorylation; and regulation of signal transduction. Predicted to be located in cytoplasm. Predicted to be part of cytosolic small ribosomal subunit and eukaryotic translation initiation factor 2 complex. Is expressed in several structures, including early conceptus; heart; lens; liver; and ovary. Orthologous to human EIF2A (eukaryotic translation initiation factor 2A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eif2a |
| Official Name | eukaryotic translation initiation factor 2A [Source:MGI Symbol;Acc:MGI:1098684] |
| Ensembl ID | ENSMUSG00000027810 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 2A |
| Synonyms | CDA02, D030048D22, D3Ertd194e, eIF2alpha, eukaryotic translation initiation factor 2A, MST089, MSTP004, MSTP089 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Eif2a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tRNA binding
- Eukaryotic translation initiation factor eIF2A
- ribosome binding
- translation initiation factor
- protein binding
- translation regulator
- phosphorylation site
Pathways
Biological processes and signaling networks where the Eif2a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- obesity
- impaired glucose tolerance
- insulin resistance
- mammary neoplasm
- fibrosis
- Alzheimer disease
- hepatomegaly
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
role in cell
- expression in
- apoptosis
- phosphorylation in
- degradation in
- activation in
- cell death
- accumulation in
- differentiation
- survival
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Eif2a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translation
- SREBP-mediated signaling pathway
- ribosome assembly
- translational initiation
- positive regulation of signal transduction
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytosolic small ribosomal subunit
- cytoplasm
- blood microparticle
- eukaryotic translation initiation factor 2 complex
Molecular Function
What the gene product does at the molecular level
- translation initiation factor activity
- protein binding
- ribosome binding
- cadherin binding
- mRNA binding
- tRNA binding