Esr2 Gene Summary [Mouse]
Enables DNA binding activity. Acts upstream of or within several processes, including hormone-mediated signaling pathway; nervous system development; and reproductive structure development. Located in cytoplasm and nucleus. Is expressed in several structures, including brain; ganglia; genitourinary system; limb segment; and mammary gland primordium. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); bone disease (multiple); hypospadias; and neurodegenerative disease (multiple). Orthologous to human ESR2 (estrogen receptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Esr2 |
| Official Name | estrogen receptor 2 (beta) [Source:MGI Symbol;Acc:MGI:109392] |
| Ensembl ID | ENSMUSG00000021055 |
| Bio databases IDs | |
| Aliases | estrogen receptor 2 (beta) |
| Synonyms | beta ESTROGEN receptor, Erb, ER[b], ERB2, ER-beta, ER-β, ESRB, ESR-BETA, ESR-β, ESTRB, estrogen receptor 2, estrogen receptor 2 (beta), estrogen receptor 2 (β), estrogen receptor beta, Estrogen receptor β, NR3A2, ODG8, β ESTROGEN receptor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Esr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc finger DNA binding domain
- LXXLL motif
- transcription regulator
- steroid hormone receptor
- A/B region
- DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
- transcription activation domain
- AF-2 transcription activation domain
- chromatin binding
- F domain
- hormone binding domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- nuclear receptor ligand binding domain
- P-box
- peroxisome proliferator activated receptor binding
- AF-1 domain
- ligand-binding domain
- estrogen receptor
- ligand-dependent nuclear receptor
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- hormone binding
- estrogen receptor C domain
- estrogen receptor A/B domain
- DNA binding domain
- amphipathic helix
- nucleic acid binding
- enzyme binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- steroid binding
- binding protein
- Estrogen receptor beta
- estrogen receptor alpha E/F domain
- double-stranded DNA binding
- hinge domain
- zinc finger domain
- Ligand-binding domain of nuclear hormone receptor
- C-terminal extension
Pathways
Biological processes and signaling networks where the Esr2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- astrocytosis
- neoplasia
- epithelial cancer
- Alzheimer disease
- pain
- obesity
- psoriasis
- major depression
- polycystic ovary syndrome
- hypertension
phenotypes
- decreased bone mineral content
- decreased bone mineral density
- decreased circulating triglyceride level
- decreased heart left ventricle size
- decreased lean body mass
- decreased leukocyte cell number
- decreased lymphocyte cell number
- decreased monocyte cell number
- increased circulating HDL cholesterol level
- increased circulating alkaline phosphatase level
- increased circulating serum albumin level
- increased circulating total protein level
- increased hemoglobin content
- increased total body fat amount
- thin ventricular wall
- abnormal B cell number
- abnormal astrocyte morphology
- abnormal auditory brainstem response
- abnormal behavior
- abnormal bone marrow cell number
- abnormal bone mineralization
- abnormal bone ossification
- abnormal cochlear IHC afferent innervation pattern
- abnormal cumulus oophorus morphology
- abnormal enterocyte apoptosis
- abnormal enterocyte morphology
- abnormal enterocyte physiology
- abnormal enterocyte proliferation
- abnormal estrous cycle
- abnormal excitatory postsynaptic potential
- abnormal germ cell morphology
- abnormal hair cycle catagen phase
- abnormal intercalated disk morphology
- abnormal large intestine crypts of Lieberkuhn morphology
- abnormal leukopoiesis
- abnormal long bone epiphyseal plate morphology
- abnormal lung morphology
- abnormal lymphopoiesis
- abnormal mammary gland epithelium morphology
- abnormal mammary gland growth during lactation
- abnormal mammary gland growth during pregnancy
- abnormal mature ovarian follicle morphology
- abnormal muscle contractility
- abnormal muscle electrophysiology
- abnormal myocardial fiber morphology
- abnormal neocortex morphology
- abnormal nociception after inflammation
- abnormal ovarian follicle morphology
- abnormal ovulation
- abnormal primary ovarian follicle morphology
- abnormal pulmonary alveolus morphology
- abnormal response/metabolism to endogenous compounds
- abnormal secondary ovarian follicle morphology
- abnormal sexual interaction
- abnormal somatosensory cortex morphology
- abnormal spatial learning
- abnormal substantia nigra morphology
- abnormal superovulation
- abnormal surfactant physiology
- abnormal synaptic plasticity
- abnormal urinary bladder morphology
- abnormal urinary bladder physiology
- abnormal urinary bladder urothelium morphology
- abnormal vascular smooth muscle morphology
- abnormal vascular smooth muscle physiology
- absent corpus luteum
- absent mature ovarian follicles
- accelerated hair follicle regression
- altered response of heart to induced stress
- altered response to myocardial infarction
- anemia
- anovulation
- ascites
- astrocytosis
- cardiac hypertrophy
- colitis
- decreased brain size
- decreased chemical nociceptive threshold
- decreased circulating glucose level
- decreased corpora lutea number
- decreased dopamine level
- decreased exploration in new environment
- decreased insulin secretion
- decreased litter size
- decreased neuron number
- decreased ovulation rate
- decreased physiological sensitivity to xenobiotic
- decreased serotonin level
- decreased vertical activity
- decreased volumetric bone mineral density
- delayed wound healing
- dilated heart ventricle
- enlarged heart
- enlarged liver
- enlarged lymph nodes
- enlarged myocardial fiber
- enlarged pancreatic islets
- enlarged spleen
- female infertility
- hypoactivity
- hyporesponsive to tactile stimuli
- impaired contextual conditioning behavior
- impaired cued conditioning behavior
- impaired ovarian folliculogenesis
- increased aggression towards males
- increased anxiety-related response
- increased body length
- increased body weight
- increased bone marrow cell number
- increased bone strength
- increased chronic myelocytic leukemia incidence
- increased circulating glucose level
- increased circulating insulin-like growth factor I level
- increased circulating luteinizing hormone level
- increased compact bone area
- increased erythrocyte cell number
- increased granulocyte number
- increased heart weight
- increased insulin sensitivity
- increased keratinocyte apoptosis
- increased leukocyte cell number
- increased megakaryocyte cell number
- increased monocyte cell number
- increased neutrophil cell number
- increased osteoblast cell number
- increased pre-B cell number
- increased pro-B cell number
- increased sensitivity to induced morbidity/mortality
- increased systemic arterial blood pressure
- increased thigmotaxis
- increased urine glycosaminoglycan level
- increased vasoconstriction
- increased vasodilation
- long femur
- male infertility
- mammary gland alveolar hyperplasia
- myelofibrosis
- neuron degeneration
- no abnormal phenotype detected
- prostate gland epithelial hyperplasia
- reduced female fertility
- reduced long term potentiation
- short ulna
- spleen hyperplasia
- spleen hypoplasia
- thin epidermis
- urinary bladder inflammation
role in cell
- expression in
- activation in
- function
- phosphorylation in
- production in
- proliferation
- number
- quantity
- activation
- recruitment in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- plasma membrane fraction
- nuclear fraction
- soluble fraction
- nuclear membrane fraction
- mitochondrial fraction
- intracellular membrane-bounded organelle
- perinuclear mitochondria
- peripheral mitochondria
- Cytoplasm
- cell surface
- perinuclear region
- Plasma Membrane
- vesicles
- Mitochondria
- cytosol
- microsome
- caveolae
- inner nuclear membrane
- nucleoplasm
- dendritic spines
- nerve ending
- chromatin
- perikaryon
- axons
- dendrites
- axon terminals
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Esr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- cellular response to estradiol stimulus
- positive regulation of transcription, DNA-dependent
- negative regulation of cell growth
- signal transduction
- cell-cell signaling
- regulation of transcription, DNA-dependent
- positive regulation of sequence-specific DNA binding transcription factor activity
- cellular response to estrogen stimulus
- intracellular estrogen receptor signaling pathway
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- intracellular membrane-bounded organelle
- mitochondrion
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- estrogen response element binding
- estrogen receptor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- receptor antagonist activity
- steroid binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- DNA binding
- protein binding
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- steroid hormone receptor activity
- enzyme binding