NPR1

NPR1 Gene Summary

Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009]

Details

Type
Protein Coding
Official Symbol
NPR1
Official Name
natriuretic peptide receptor 1 [Source:HGNC Symbol;Acc:HGNC:7943]
Ensembl ID
ENSG00000169418
Bio databases IDs NCBI: 4881 Ensembl: ENSG00000169418
Aliases natriuretic peptide receptor 1, guanylate cyclase A
Synonyms
ANPa,ANPRA,GC-A,Gc alpha,Gc α,Guanylate cyclase,GUC2A,GUCY2A,natriuretic peptide receptor 1,NPR-A,Particulate GC-A,pGC-A,Pndr
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • natriuretic peptide receptor
  • Receptor family ligand binding region
  • hormone binding
  • Protein kinase (unclassified specificity)
  • guanylate cyclase domain
  • catalytic domain
  • Protein tyrosine and serine/threonine kinase
  • kinase-like domain
  • enzyme
  • protein binding
  • Protein kinase domain
  • polypeptide hormone binding
  • Serine/Threonine protein kinases, catalytic domain
  • Protein Kinases, catalytic domain
  • cytoplasmic domain
  • transmembrane/cytoplasmic domain
  • Type 1 periplasmic binding fold superfamily
  • guanylate cyclase
  • intracellular domain
  • Class III nucleotidyl cyclases
  • Adenylyl- / guanylyl cyclase, catalytic domain
  • Tyrosine kinase, catalytic domain

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
  • NPR1
  • atrial natriuretic peptide
  • NPPA
  • PPP5C
  • isosorbide dinitrate
  • nesiritide
  • nitroprusside
  • SEMA3A
  • TRPC6
  • NPPB
disease
  • neoplasia
  • coronary artery disease
  • hypertension
  • cardiomyopathy
  • heart failure
  • fibrosis
  • heart disease
  • perivascular fibrosis
  • congestive heart failure
  • cardiac hypertrophy
regulated by
  • BDNF
  • beta-estradiol
  • LEP
  • NPPA
  • sodium chloride
  • NFYA
  • p38 MAPK
  • NPPB
  • SB203580
  • TGFB1
regulates
  • NFkB (complex)
  • TNF
  • creatinine
  • IL6
  • IL1B
  • RELA
  • VEGFA
  • p38 MAPK
  • Ca2+
  • CCL2
role in cell
  • expression in
  • quantity
  • phosphorylation in
  • apoptosis
  • proliferation
  • chemotaxis
  • size
  • dissociation
  • cross-sectional area
  • cellular infiltration by

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • plasma membrane fraction
  • cell surface
  • cellular membrane
  • podocyte slit diaphragm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the NPR1 gene, providing context for its role in the cell.

BIOLOGICAL PROCESS

Functions and activities the gene product is involved in
  • negative regulation of angiogenesis
  • cGMP biosynthetic process
  • cGMP-mediated signaling
  • dopamine metabolic process
  • G-protein coupled receptor signaling pathway
  • receptor guanylyl cyclase signaling pathway
  • regulation of vascular permeability
  • cell surface receptor signaling pathway
  • regulation of blood pressure
  • body fluid secretion
  • positive regulation of renal sodium excretion
  • negative regulation of cell growth
  • negative regulation of smooth muscle cell proliferation
  • positive regulation of cGMP-mediated signaling
  • positive regulation of urine volume

CELLULAR COMPONENT

Where in the cell the gene product is active
  • receptor complex
  • plasma membrane

MOLECULAR FUNCTION

What the gene product does at the molecular level
  • GTP binding
  • peptide receptor activity
  • ATP binding
  • G-protein coupled peptide receptor activity
  • hormone binding
  • guanylate cyclase activity
  • protein kinase activity
  • peptide hormone binding
  • adenylate cyclase activity
  • natriuretic peptide receptor activity

Gene-Specific Assays for Results You Can Trust

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