Pax5 Gene Summary [Mouse]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including embryonic cranial skeleton morphogenesis; skeletal muscle cell differentiation; and telencephalon development. Located in nucleus. Is expressed in several structures, including central nervous system; future brain; immune system; liver; and urinary system. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to human PAX5 (paired box 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pax5 |
| Official Name | paired box 5 [Source:MGI Symbol;Acc:MGI:97489] |
| Ensembl ID | ENSMUSG00000014030 |
| Bio databases IDs | |
| Aliases | paired box 5 |
| Synonyms | ALL3, B-cell lineage specific activator, BSAP, EBB-1, KLP, paired box 5, RGD1565236 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pax5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- DNA binding domain
- nucleic acid binding
- Groucho binding domain
- nuclear localization sequence
- HTH_ARSR
- octapeptide domain
- transcription activation domain
- inhibitory domain
- protein binding
- sequence-specific DNA binding
- HTH_CRP
- Paired-box protein 2 C terminal
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- 'Paired box' domain
- transcription factor activity
- Paired Box domain
Pathways
Biological processes and signaling networks where the Pax5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-small cell lung cancer
- anxiety disorder
- coronary artery disease
- non-small cell lung carcinoma
- PAX5-associated susceptibility to leukemia
- insomnia
- precursor B-cell acute lymphoblastic leukemia
- susceptibility to acute lymphoblastic leukemia type 3
- metabolic syndrome X
phenotypes
- abnormal auditory brainstem response
- decreased leukocyte cell number
- hyperactivity
- impaired glucose tolerance
- increased cardiac muscle contractility
- increased circulating triglyceride level
- preweaning lethality complete penetrance
- abnormal B cell differentiation
- abnormal B cell physiology
- abnormal cell adhesion
- abnormal cell migration
- abnormal cerebellar foliation
- abnormal cerebellar lobule formation
- abnormal cerebellum morphology
- abnormal cerebellum vermis morphology
- abnormal hindbrain development
- abnormal humoral immune response
- abnormal immunoglobulin heavy chain V(D)J recombination
- abnormal late pro-B cell
- abnormal locomotor activation
- abnormal lymphopoiesis
- absent B-2 B cells
- absent late pro-B cells
- absent mature B cells
- arrested B cell differentiation
- decreased B cell number
- decreased B-1 B cell number
- decreased B-1b cell number
- decreased IgA level
- decreased IgD level
- decreased IgG level
- decreased IgG1 level
- decreased IgG2a level
- decreased IgG2b level
- decreased IgM level
- decreased body size
- decreased body weight
- decreased immature B cell number
- decreased immunoglobulin level
- decreased inferior colliculus size
- impaired humoral immune response
- increased B-1 B cell number
- increased CD4-positive CD25-positive alpha-beta regulatory T cell number
- increased CD8-positive alpha-beta memory T cell number
- increased T cell number
- increased macrophage cell number
- increased monocyte cell number
- increased single-positive T cell number
- lethality at weaning complete penetrance
- limb grasping
- no abnormal phenotype detected
- postnatal growth retardation
- postnatal lethality incomplete penetrance
- premature death
role in cell
- growth
- proliferation
- cell death
- upregulation in
- expression in
- induction
- activation
- activation in
- loss
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pax5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- B cell differentiation
- spermatogenesis
- anatomical structure development
- embryonic cranial skeleton morphogenesis
- transcription from RNA polymerase II promoter
- cerebral cortex development
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- lateral ventricle development
- skeletal muscle cell differentiation
- adult behavior
Cellular Component
Where in the cell the gene product is active
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity