Ctsl Gene Summary [Mouse]
This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the activation peptide and the cathepsin L1 heavy and light chains. The mature enzyme appears to be important in embryonic development through its processing of histone H3 and may play a role in disease progression in a model of kidney disease. Homozygous knockout mice for this gene exhibit hair loss, skin thickening, bone and heart defects, and enhanced susceptibility to bacterial infection. A pseudogene of this gene has been identified in the genome. [provided by RefSeq, Aug 2015]
Details
| Type | Protein Coding |
| Official Symbol | Ctsl |
| Official Name | cathepsin L [Source:MGI Symbol;Acc:MGI:88564] |
| Ensembl ID | ENSMUSG00000021477 |
| Bio databases IDs | |
| Aliases | cathepsin L |
| Synonyms | 1190035F06RIK, cathepsin L, CATL, CTSL1, Ctsl2, fs, MEP, nkt |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ctsl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptide binding
- histone binding
- Cathepsin propeptide inhibitor domain (I29)
- peptidase
- Peptidase_C1
- enzyme
- protein binding
- fibronectin binding
- cathepsin L
- endopeptidase
- cysteine-type peptidase
- cysteine endopeptidase
- binding protein
- aminopeptidase
- collagen binding
- cysteine-type carboxypeptidase
Pathways
Biological processes and signaling networks where the Ctsl gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- cancer
- diabetic nephropathy
- pancreatic neoplasia
- insulitis
- membranous glomerulonephritis
- epidermal hyperplasia
- insulin-dependent diabetes mellitus
- leiomyosarcoma
- soft tissue sarcoma cancer
phenotypes
- abnormal CD4-positive T cell differentiation
- abnormal CD8-positive alpha beta T cell morphology
- abnormal CD8-positive alpha-beta T cell differentiation
- abnormal R wave
- abnormal T cell differentiation
- abnormal T wave
- abnormal cardiovascular system physiology
- abnormal cartilage morphology
- abnormal coat appearance
- abnormal coat/ hair morphology
- abnormal epidermis stratum basale morphology
- abnormal external auditory canal morphology
- abnormal hair cycle
- abnormal hair cycle catagen phase
- abnormal hair follicle development
- abnormal hair follicle morphology
- abnormal hair follicle orientation
- abnormal hair growth
- abnormal hair shaft morphology
- abnormal heart echocardiography feature
- abnormal heart electrocardiography waveform feature
- abnormal heartbeat
- abnormal immune system organ morphology
- abnormal keratinocyte physiology
- abnormal leukocyte cell number
- abnormal lymph node cortex morphology
- abnormal lymph node morphology
- abnormal lysosome morphology
- abnormal myocardial fiber morphology
- abnormal myocardium layer morphology
- abnormal osteoclast physiology
- abnormal seminiferous tubule morphology
- abnormal spermatogenesis
- abnormal thymus corticomedullary boundary morphology
- abnormal thymus lobule morphology
- abnormal thymus morphology
- abnormal thyroid gland morphology
- abnormal thyroid hormone level
- abnormal trabecular bone morphology
- abnormal visceral endoderm morphology
- abnormal visceral yolk sac morphology
- absent vibrissae
- acanthosis
- alopecia
- amyloidosis
- aortic valve regurgitation
- atrioventricular block
- cachexia
- cardiac interstitial fibrosis
- corneal opacity
- decreased CD4-positive alpha beta T cell number
- decreased alpha-beta T cell number
- decreased body size
- decreased cardiac muscle contractility
- decreased long bone epiphyseal plate size
- decreased osteoclast cell number
- decreased susceptibility to autoimmune diabetes
- decreased testis weight
- decreased thyroxine level
- decreased ventricle muscle contractility
- delayed hair appearance
- dental pulp necrosis
- dermatitis
- dilated cardiomyopathy
- dilated lymph node medullary sinus
- dilated piliary canal
- enlarged heart
- enlarged heart left atrium
- enlarged lymph nodes
- enlarged sebaceous gland
- enlarged thymus cortex
- epidermal hyperplasia
- excessive scratching
- focal dorsal hair loss
- folliculitis
- granulomatous inflammation
- greasy coat
- hair follicle outer root sheath hyperplasia
- heart left ventricle hypertrophy
- hyperglycemia
- hypergranulosis
- hyperkeratosis
- increased CD8-positive alpha-beta T cell number
- increased alpha-beta T cell number
- increased central memory CD4-positive alpha-beta T cell number
- increased central memory CD8 positive alpha-beta T cell number
- increased effector memory CD4-positive alpha-beta T cell number
- increased heart rate
- increased heart weight
- increased inflammatory response
- increased keratinocyte proliferation
- increased regulatory T cell number
- insulitis
- liver inflammation
- lymph node hyperplasia
- lymph node inflammation
- mitral valve regurgitation
- orthokeratosis
- periodontal ligament necrosis
- postnatal growth retardation
- postnatal lethality incomplete penetrance
- rough coat
- salivary gland inflammation
- scaly skin
- shiny skin
- short hair
- short vibrissae
- skin lesions
- sparse hair
- sparse vibrissae
- thick dermal layer
- thick epidermis
- thick skin
- thymus atrophy
- underdeveloped hair follicles
role in cell
- apoptosis
- expression in
- proliferation
- tumorigenicity
- growth
- activation in
- number
- generation in
- degradation in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- late endoplasmic reticulum derived secretory vesicle
- Golgi region
- Extracellular Space
- intracellular space
- apical compartment
- perinuclear region
- organelle lumens
- podosomes
- Nucleus
- Plasma Membrane
- endosomes
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- membrane compartment
- plasma membrane extracellular face
- lysosomal compartment
- endosomal compartment
- nucleoli
- neurites
- cytotoxic granule
- cytoplasmic vesicles
- secretory vesicles
- multivesicular bodies
- secretory granules
- microvilli
- perikaryon
- chromaffin vesicles
- phagosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ctsl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- enkephalin processing
- adaptive immune response
- cellular response to thyroid hormone stimulus
- zymogen activation
- immune response
- viral entry into host cell via receptor-mediated endocytosis
- elastin catabolic process
- viral envelope fusion with host membrane
- antigen processing and presentation of peptide antigen
- proteolysis
- CD4-positive, alpha-beta T cell lineage commitment
- positive regulation of peptidase activity
- antigen processing and presentation
- collagen catabolic process
- protein autoprocessing
- proteolysis involved in cellular protein catabolic process
- antigen processing and presentation of exogenous peptide antigen via MHC class II
- macrophage apoptotic process
- positive regulation of apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- endolysosome lumen
- chromaffin granule
- Golgi apparatus
- lysosomal lumen
- multivesicular body
- extracellular region
- plasma membrane
- lysosome
- nucleus
- extracellular space
- extracellular vesicular exosome
- endocytic vesicle lumen
- intracellular membrane-bounded organelle
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- proteoglycan binding
- collagen binding
- histone binding
- cysteine-type endopeptidase activity
- fibronectin binding
- cysteine-type peptidase activity
- cysteine-type endopeptidase activator activity involved in apoptotic process