SIRT2 Gene Summary
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010]
Details
| Type | Retained Intron |
| Official Symbol | SIRT2 |
| Official Name | sirtuin 2 [Source:HGNC Symbol;Acc:HGNC:10886] |
| Ensembl ID | ENSG00000068903 |
| Bio databases IDs | |
| Aliases | sirtuin 2 |
| Synonyms | 5730427M03Rik,SIR2,SIR2L,SIR2L2,sirtuin 2 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- NAD ADP-ribosyltransferase
- NAD-dependent histone deacetylase activity (H4-K16 specific)
- transcription factor binding
- histone deacetylase binding
- chromatin binding
- ubiquitin binding
- protein binding
- enzyme
- protein deacetylase activity
- NAD or NADH binding
- NAD-dependent histone deacetylase
- binding protein
- zinc ion binding
- histone deacetylase
- tubulin deacetylase
- SIR2
- Non-amino-acyl group acyltransferase
- histone acetyltransferase binding
Pathways
Biological processes and signaling networks where the SIRT2 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- epithelial neoplasia
- epithelial cancer
- cancer
- cardiac hypertrophy
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
- neoplasia
role in cell
- expression in
- proliferation
- survival
- migration
- differentiation
- apoptosis
- growth
- maturation
- accumulation in
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- myelin enriched fraction
- glutaminergic synapse
- axon component
- heterochromatin
- spindle apparatus
- Cytoplasm
- perinuclear region
- Plasma Membrane
- centrosome
- centriole
- Mitochondria
- microtubules
- midbody
- cytosol
- chromosome
- nucleoli
- spindle fibers
- myelin sheath outer loop
- paranodal loops
- paranodes
- paranodal junctions
- myelin sheath
- Schmidt-Lanterman incisures
- glial cell projections
- mitotic spindle
- meiotic spindles
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the SIRT2 gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
- positive regulation of oocyte maturation
- cellular response to caloric restriction
- regulation of exit from mitosis
- negative regulation of protein catabolic process
- positive regulation of DNA binding
- positive regulation of transcription from RNA polymerase II promoter
- post-translational protein modification
- positive regulation of execution phase of apoptosis
- negative regulation of striated muscle tissue development
- positive regulation of fatty acid biosynthetic process
- cell division
- negative regulation of transcription from RNA polymerase II promoter
- myelination in peripheral nervous system
- meiotic cell cycle
- negative regulation of transcription, DNA-dependent
- positive regulation of cell division
- chromatin silencing at rDNA
- cellular response to epinephrine stimulus
- autophagy
- cellular lipid catabolic process
- negative regulation of oligodendrocyte progenitor proliferation
- peptidyl-lysine deacetylation
- regulation of cell cycle
- cellular response to hypoxia
- positive regulation of attachment of spindle microtubules to kinetochore
- negative regulation of reactive oxygen species metabolic process
- mitotic nuclear envelope reassembly
- positive regulation of meiosis
- negative regulation of fat cell differentiation
- protein deacetylation
- tubulin deacetylation
- NLRP3 inflammasome complex assembly
- negative regulation of NLRP3 inflammasome complex assembly
- regulation of phosphorylation
- substantia nigra development
- regulation of gene expression, epigenetic
- response to redox state
- proteasomal ubiquitin-dependent protein catabolic process
- telomeric heterochromatin assembly
- negative regulation of peptidyl-threonine phosphorylation
- negative regulation of autophagy
- innate immune response
- heterochromatin assembly
- regulation of myelination
- cellular response to oxidative stress
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
cellular COMPONENT
Where in the cell the gene product is active
- myelin sheath
- chromosome
- nucleolus
- perikaryon
- chromatin silencing complex
- microtubule
- growth cone
- chromosome, telomeric region
- mitotic spindle
- cytosol
- meiotic spindle
- lateral loop
- paranode region of axon
- paranodal junction
- juxtaparanode region of axon
- plasma membrane
- nucleus
- heterochromatin
- centrosome
- perinuclear region of cytoplasm
- cytoplasm
- centriole
- Schmidt-Lanterman incisure
- mitochondrion
- spindle
- midbody
molecular FUNCTION
What the gene product does at the molecular level
- zinc ion binding
- histone acetyltransferase binding
- tubulin deacetylase activity
- histone deacetylase binding
- chromatin binding
- transcription factor binding
- NAD+ ADP-ribosyltransferase activity
- protein binding
- NAD-dependent protein deacetylase activity
- ubiquitin binding
- NAD-dependent histone deacetylase activity (H4-K16 specific)
- histone deacetylase activity
- NAD-dependent histone deacetylase activity
- protein deacetylase activity
- NAD+ binding