Plk3 Gene Summary [Rat]
Predicted to enable p53 binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including microtubule cytoskeleton organization; positive regulation of protein catabolic process; and regulation of cell cycle process. Located in dendrite and neuronal cell body. Orthologous to human PLK3 (polo like kinase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plk3 |
| Official Name | polo-like kinase 3 [Source:RGD Symbol;Acc:62039] |
| Ensembl ID | ENSRNOG00000018484 |
| Bio databases IDs | |
| Aliases | polo-like kinase 3 |
| Synonyms | CNK, FNK, Polo-like kinase 3, PRK |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Plk3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- POLO box duplicated region
- Protein kinase (unclassified specificity)
- protein kinase
- Protein tyrosine and serine/threonine kinase
- p53 binding
- protein binding
- Protein kinase domain
- POLO_box
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- pact binding motif
- dsRNA-binding domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Plk3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- epithelial neoplasia
- epithelial cancer
- neoplasia
- androgenic alopecia
- lung carcinoma process
- epileptic seizure
- non-small cell lung cancer
- lung adenocarcinoma formation
- non-squamous non-small cell lung cancer
role in cell
- apoptosis
- binding in
- phosphorylation in
- expression in
- G2/M phase
- proliferation
- invasion by
- replication in
- response
- fragmentation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- cellular membrane
- cell cortex
- Plasma Membrane
- centrosome
- Golgi Apparatus
- midbody
- microtubule organizing centers
- Golgi stacks
- nucleoplasm
- nucleoli
- spindle pole
- mitotic spindle
- meiotic spindles
- chromatin
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Plk3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of intracellular protein transport
- Golgi disassembly
- mitotic spindle organization
- response to osmotic stress
- response to radiation
- endomitotic cell cycle
- protein phosphorylation
- response to DNA damage stimulus
- response to reactive oxygen species
- negative regulation of transcription from RNA polymerase II promoter
- regulation of cell division
- G2/M transition of mitotic cell cycle
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
- negative regulation of apoptotic process
- G1/S transition of mitotic cell cycle
- apoptotic process
- regulation of cytokinesis
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia
- cytoplasmic microtubule organization
- negative regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- dendrite
- centrosome
- cytoplasm
- spindle pole
- kinetochore
- neuronal cell body
- nucleolus
- Golgi stack
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- p53 binding
- protein binding
- protein serine/threonine kinase activity