EXOC5 Gene Summary [Human]

The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
EXOC5
Official Name
exocyst complex component 5 [Source:HGNC Symbol;Acc:HGNC:10696]
Ensembl ID
ENSG00000070367
Bio databases IDs NCBI: 10640 Ensembl: ENSG00000070367
Aliases exocyst complex component 5
Synonyms AI447711, exocyst complex component 5, Gm76, HSEC10, PRO1912, SEC10, SEC10L1, SEC10P
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EXOC5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • enzyme binding
  • Exocyst complex component Sec10
  • protein binding

Pathways

Biological processes and signaling networks where the EXOC5 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • proteinuria
  • renal fibrosis
  • Hutchinson-Gilford progeria syndrome
  • primary central nervous system lymphoma
  • primary cancer
  • lymphomagenesis
  • central nervous system cancer
regulated by
  • ESR1
  • NCAM1
  • FGFR
  • puromycin aminonucleoside
  • guanosine triphosphate
regulates
role in cell
  • expression in
  • phosphorylation in
  • number
  • loss
  • formation
  • formation in
  • apoptosis
  • morphology
  • assembly
  • outgrowth

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • endosomal bud
  • perinuclear region
  • vesicles
  • cytosol
  • trans Golgi network
  • recycling endosomes

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human EXOC5 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • membrane fission
  • cytokinesis after mitosis
  • establishment of planar polarity
  • vesicle docking involved in exocytosis
  • protein transport
  • Golgi to plasma membrane transport
  • post-Golgi vesicle-mediated transport
  • exocytosis
  • protein localization in plasma membrane

Cellular Component

Where in the cell the gene product is active
  • cytoplasm
  • cytosol
  • midbody
  • exocyst

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • small GTPase binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.