Target List
Insulin Signaling
Akt3, Gys1, Igf1, Igf1r, Ikbkb (IKK2), Insr, Irs1, Irs2, Map2k1 (MEK1), Mapk3 (ERK1), Mapk9 (Jnk2), Mtor, Pde3b, Pik3ca (p110-alpha), Pik3r1 (PI3KA), Ppargc1a, Ptpn1 (Ptp), Rps6kb1, Slc2a4 (Glut4), Socs3, Srebf1
Non-Insulin Dependent Diabetes Mellitus
Adipoq, Hk2, Ikbkb (IKK2), Insr, Irs1, Irs2, LOC103694380 (Tnf), Mapk3 (ERK1), Mapk9 (Jnk2), Mtor, Pdx1 (Ipf1), Pik3ca (p110-alpha), Pik3r1 (PI3KA), Slc2a4 (Glut4), Socs3
Adipokine Signaling
Adipokines
Adipoq, Il6, Lep (Leptin), LOC103694380 (Tnf), Nampt, Retn, Serpine1 (Pai-1)
Receptors & Transporters
Adipor1, Adipor2, Cd36 (QuantiNova Symbol: RGD1565355), Lepr, Slc2a4 (Glut4), Tnfrsf1a (Tnfr1), Tnfrsf1b
Signaling Downstream of Adipokines
Akt3, Chuk (Ikbka, Ikka), Ikbkb (IKK2), Irs1, Irs2, Jak2, Mapk9 (Jnk2), Mtor, Nfkbia (Iκbα, Mad3), Ppara, Ppargc1a, Rela, Socs3, Stat3
Innate Immunity
Casp1 (Ice), Chuk (Ikbka, Ikka), Ikbkb (IKK2), Irs1, Irs2, Nfkbia (Iκbα, Mad3), Nlrp3, Pycard (Tms1, Asc), Rela, Tlr4
Inflammation
Alox5, Casp1 (Ice), Ccl12, Ccr4, Ccr5, Chuk (Ikbka, Ikka), Cxcr4, Ifng, Ikbkb (IKK2), Il1b, Il23r, Il6, LOC103694380 (Tnf), Lta4h, Nlrp3, Olr1, Pycard (Tms1, Asc), Rela, Tnfrsf1a (Tnfr1), Tnfrsf1b
Apoptosis
Casp1 (Ice), Ikbkb (IKK2), Irs2, Jak2, LOC103694380 (Tnf), Mapk9 (Jnk2), Nfkbia (Iκbα, Mad3), Nlrp3, Pik3ca (p110-alpha), Pparg, Pycard (Tms1, Asc), Rela, Rps6kb1, Serpine1 (Pai-1), Socs3, Tnfrsf1a (Tnfr1), Tnfrsf1b
Metabolic Pathways
Carbohydrate Metabolism
Cs, Gys1, Hk2, Pck1, Pdk2
Lipid Metabolism
Acaca, Acacb, Acsl1, Acsl4, Apoe, Cebpa, Cnbp, Fabp4, Fasn, Lepr, Lipe, Lpl, Ppara, Pparg, Ppargc1a, Scd, Srebf1, Srebf2
Metabolite Transport
Apoe, Cd36 (QuantiNova Symbol: RGD1565355), Fabp4, Rbp4, Slc27a1, Slc2a4 (Glut4), Ucp1, Vldlr
Infiltrating Leukocyte Markers
Macrophages
Adgre1, Ccr5, Cxcr4
Th1 Cells
Ccr5, Cd3e, Cxcr3, Il18r1
Th2 Cells
Ccr4, Cd3e, Crlf2, Il1r1
Th17 Cells
Ccr6, Cd3e, Il23r