Target List
Apoptosis
BCL2, BIRC5
PI3 Kinases & Phosphatases
MTOR, PIK3C2A, PIK3C3 (VPS34), PIK3CA (p110-alpha)
Growth Factors & Receptors
EGFR (ERBB1), ERBB2 (HER-2, NEU), ERBB3, ERBB4, FLT1 (VEGFR1), FLT4 (VEGFR2), IGF1, IGF1R, IGF2, KDR (VEGFR3), KIT (CD117), PDGFRA, PDGFRB, VEGFD (VEGFD)
Drug Metabolism
ABCC1 (MRP1), GSTP1, PTGS2 (COX2), TXN, TXNRD1
G-Protein Signaling
RHOA, RHOB
Hormone Receptors
ESR1 (ERα), ESR2 (ERβ), PGR
Heat Shock Proteins
HSP90AA1, HSP90B1
Receptor Tyrosine Kinase Signaling
AKT1, AKT2, GRB2
Cathepsins
CTSB, CTSD, CTSL, CTSS
Cell Cycle
CDC25A, CDK1, CDK2, CDK4, CDK5, CDK7, CDK8, CDK9, MDM2, MDM4, TERT
Topoisomerases, Type II
TOP2A, TOP2B
Transcription Factors
ATF2 (CREB2), HIF1A, IRF5, NFKB1, TP53 (p53)
Protein Kinases
AURKA, AURKB, AURKC, PLK1, PLK2, PLK3, PLK4, PRKCA, PRKCB, PRKCD, PRKCE
RAS Signaling
HRAS, KRAS, NRAS
Histone Deacetylases
HDAC1, HDAC11, HDAC2, HDAC3, HDAC4, HDAC6, HDAC7, HDAC8
Poly ADP-Ribose Polymerases
PARP1 (ADPRT1), PARP2, PARP4, TNKS (TIN1)
Structural Proteins
NTN3