DCN Gene Summary [Human]
This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015]
Details
| Type | Protein Coding |
| Official Symbol | DCN |
| Official Name | decorin [Source:HGNC Symbol;Acc:HGNC:2705] |
| Ensembl ID | ENSG00000011465 |
| Bio databases IDs | |
| Aliases | decorin, decorin proteoglycan |
| Synonyms | Bone proteoglycan II, CSCD, DC, Decorin, DSPG2, PG40, PGII, PGS2, SLRR1B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DCN often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- leucine-rich repeat
- protein phosphatase 1 regulatory subunit 42
- core
- extracellular matrix structural constituent conferring compression resistance
- extracellular matrix binding
- Leucine rich repeat
- collagen binding
- Leucine rich repeat N-terminal domain
- protein binding
- Leucine Rich repeats (2 copies)
- glycosaminoglycan binding
Pathways
Biological processes and signaling networks where the DCN gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- adenoma formation
- tumorigenesis
- cancer
- fibrosis
- epithelial cancer
- hepatocellular carcinoma
- tubulo-interstitial fibrosis
- congenital stromal corneal dystrophy
- endometrial adenocarcinoma
role in cell
- apoptosis
- proliferation
- expression in
- migration
- activation in
- growth
- binding in
- invasion by
- number
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
- cell surface
- lysosomal compartment
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DCN gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of autophagy
- positive regulation of macroautophagy
- negative regulation of vascular endothelial growth factor signaling pathway
- negative regulation of angiogenesis
- positive regulation of mitochondrial depolarization
- positive regulation of mitochondrial fission
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of endothelial cell migration
- positive regulation of protein kinase B signaling cascade
- organ morphogenesis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- lysosomal lumen
- Golgi lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- extracellular matrix binding
- RNA binding
- protein binding
- glycosaminoglycan binding
- extracellular matrix structural constituent conferring compression resistance