Target List
Pro-Fibrotic
Acta2, Agt, Ccl11 (Eotaxin), Ccl12, Ccl3 (Mip-1a), Ccn2, Grem1, Il13, Il13ra2, Il4, Il5, Snai1 (Snail, Sna)
Anti-Fibrotic
Bmp7, Hgf, Ifng, Il10, Il13ra2
Extracellular Matrix (ECM) & Cell Adhesion Molecules
Extracellular Matrix (ECM) Structural Constituents
Col1a2, Col3a1
Extracellular Matrix (ECM) Remodeling Enzymes
Lox, Mmp1, Mmp13, Mmp14, Mmp2, Mmp3, Mmp8, Mmp9, Plat (tPA), Plau (UPAM), Plg, Serpina1, Serpine1 (Pai-1), Serpinh1 (Hsp47), Timp1, Timp2, Timp3, Timp4
Cell Adhesion Molecules
Itga1, Itga2, Itga3, Itgav, Itgb1, Itgb3, Itgb5, Itgb6, Itgb8
Inflammatory Cytokines & Chemokines
Ccl11 (Eotaxin), Ccl12, Ccl3 (Mip-1a), Ccr7, Cxcr4, Ifng, Il10, Il13, Il13ra2, Il1a, Il1b, Il4, Il5, Ilk, LOC103694380 (Tnf)
Growth Factors
Agt, Ccn2, Edn1, Egf, Hgf, Pdgfa, Pdgfb, Vegfa
Signal Transduction
TGFβ Superfamily Members
Bmp7, Cav1, Dcn, Eng (Evi-1), Grem1, Inhbe, Ltbp1, Smad2, Smad3, Smad4, Smad6, Smad7, Tgfb1, Tgfb2, Tgfb3, Tgfbr1 (Alk5), Tgfbr2, Tgif1, Thbs1 (TSP-1, Tsp1), Thbs2
Transcription Factors
Cebpb, Jun, Myc, Nfkb1, Sp1, Stat1, Stat6
Epithelial-to-Mesenchymal Transition (EMT)
Akt1, Bmp7, Col1a2, Col3a1, Ilk, Itgav, Itgb1, Mmp2, Mmp3, Mmp9, Serpine1 (Pai-1), Smad2, Snai1 (Snail, Sna), Tgfb1, Tgfb2, Tgfb3, Timp1
Other Fibrosis Genes
Bcl2, Faslg