FNBP1L
FNBP1L Gene Summary
The protein encoded by this gene binds to both CDC42 and N-WASP. This protein promotes CDC42-induced actin polymerization by activating the N-WASP-WIP complex and, therefore, is involved in a pathway that links cell surface signals to the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | FNBP1L |
| Official Name | formin binding protein 1 like [Source:HGNC Symbol;Acc:HGNC:20851] |
| Ensembl ID | ENSG00000137942 |
| Bio databases IDs | |
| Aliases | formin binding protein 1 like |
| Synonyms | 2610318I01Rik,C1ORF39,FLJ20275,formin binding protein 1-like,RGD1305386,TOCA1 |
| Species | Human, homo_sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cdc42 binding domain
- enzyme binding
- Fes/CIP4, and EFC/F-BAR homology domain
- protein binding
- Bin/Amphiphysin/Rvs domain
- HR1
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the FNBP1L gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- RIN3
- DLG4
- CDC42
- RPS16
- CAPZB
- SH3PXD2A
- STING1
- PML
- GIPC1
- EFTUD2
disease
- metastasis
- Waldenström macroglobulinemia
- cleft lip
- infiltrating ductal breast carcinoma
- invasive ductal breast cancer
regulated by
- lipopolysaccharide
- EGF
- APP
- prostaglandin E2
- GH1
- FNBP1L
- HRAS
- DDIT3
- 17beta-estradiol-BSA
- EGFR
regulates
- actin
- ECM
- WASL/WIP
- WIPF1
- ARPC2
- POU5F1
- CTTN
- FNBP1L
- ABI1
- IQUB
role in cell
- generation in
- generation
- size
- quantity
- formation
- migration
- invasion by
- formation in
- invasiveness
- branching
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- invadopodia
- perinuclear region
- vesicles
- cytosol
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the FNBP1L gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- clathrin-mediated endocytosis
- membrane tubulation
- membrane budding
- cilium morphogenesis
- vesicle organization
- vesicle transport along actin filament
- signal transduction
- autophagy
- positive regulation of filopodium assembly
- membrane invagination
CELLULAR COMPONENT
Where in the cell the gene product is active
- cytoskeleton
- cytoplasm
- cell cortex
- cytosol
- cytoplasmic vesicle
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- GTPase binding
- cadherin binding
- lipid binding