Il2rb Gene Summary [Mouse]
The interleukin 2 receptor is composed of alpha and beta subunits. The beta subunit encoded by this gene is very homologous to the human beta subunit and also shows structural similarity to other cytokine receptors. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Il2rb |
| Official Name | interleukin 2 receptor, beta chain [Source:MGI Symbol;Acc:MGI:96550] |
| Ensembl ID | ENSMUSG00000068227 |
| Bio databases IDs | |
| Aliases | interleukin 2 receptor, beta chain |
| Synonyms | CD122, IL15RB, IL-15R beta, IL-15R β, Il-2/15Rbeta, IL2RBC, Il-2Rbeta, Il2r β, Il2r β C, IMD63, interleukin 2 receptor, beta chain, interleukin 2 receptor subunit beta, interleukin 2 receptor subunit β, interleukin 2 receptor, β chain, p70, P70-75 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Il2rb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- protein binding
- Fibronectin type 3 domain
- acidic domain
- interleukin-2 receptor
- Stat5 binding domain
- interleukin-2 binding
- WSXWS motif
- Shc binding site
- serine-rich region
- cytoplasmic domain
- signal sequence domain
- FN3
- interleukin-15 receptor
- transmembrane domain
- intracellular domain
- Interleukin-2 receptor subunit beta N-terminal domain 1
- cytosolic tail domain
- transmembrane receptor
- A domain
- coreceptor
Pathways
Biological processes and signaling networks where the Il2rb gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Crosstalk between Dendritic Cells and Natural Killer Cells
- FAK Signaling
- Glucocorticoid Receptor Signaling
- iCOS-iCOSL Signaling in T Helper Cells
- IL-15 Signaling
- IL-2 Signaling
- Molecular Mechanisms of Cancer
- Natural Killer Cell Signaling
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- STAT3 Pathway
- Telomerase Signaling
- Th1 and Th2 Activation Pathway
- Th2 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- refractory anemia with excess blasts
- chronic myelomonocytic leukemia
- refractory anemia with excess blasts in transformation
- bipolar disorder
- kidney disease
- mycosis fungoides
- Sézary syndrome
- renal clear cell adenocarcinoma
- cutaneous melanoma
- stage 2 neuroblastoma
phenotypes
- female infertility
- male infertility
- abnormal B cell activation
- abnormal CD8-positive alpha-beta T cell differentiation
- abnormal T cell activation
- abnormal T cell clonal deletion
- abnormal T cell morphology
- abnormal common myeloid progenitor cell morphology
- abnormal hair texture
- abnormal immune system organ morphology
- abnormal locomotor behavior
- abnormal lymphocyte morphology
- abnormal marginal zone B cell morphology
- abnormal mononuclear cell morphology
- abnormal response to transplant
- abnormal sex gland morphology
- abnormal spleen periarteriolar lymphoid sheath morphology
- decreased B cell number
- decreased CD4-positive alpha beta T cell number
- decreased CD8-positive alpha-beta T cell number
- decreased CD8-positive naive alpha-beta T cell number
- decreased NK T cell number
- decreased NK cell number
- decreased T cell proliferation
- decreased central memory CD8 positive alpha-beta T cell number
- decreased double-positive T cell number
- decreased memory T cell number
- decreased regulatory T cell number
- enlarged lymph nodes
- enlarged spleen
- increased CD4-positive alpha beta T cell number
- increased CD8-positive alpha-beta T cell number
- increased IgE level
- increased IgG1 level
- increased IgM level
- increased activated T cell number
- increased anti-double stranded DNA antibody level
- increased anti-nuclear antigen antibody level
- increased effector memory CD4-positive alpha-beta T cell number
- increased effector memory CD8-positive alpha-beta T cell number
- increased erythroid progenitor cell number
- increased granulocyte number
- increased neutrophil cell number
- increased plasma cell number
- increased susceptibility to autoimmune hemolytic anemia
- liver inflammation
- premature death
- thymus hypoplasia
- weight loss
role in cell
- growth
- proliferation
- production in
- activation in
- phosphorylation in
- apoptosis
- expression in
- number
- binding in
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble membrane fraction
- membrane fraction
- Cytoplasm
- cell surface
- cell borders
- perinuclear region
- cellular membrane
- endosomes
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Il2rb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- macromolecular complex assembly
- interleukin-2-mediated signaling pathway
- signal transduction
- cytokine-mediated signaling pathway
- negative regulation of apoptotic process
- immunoglobulin mediated immune response
- interleukin-15-mediated signaling pathway
- positive regulation of phagocytosis
Cellular Component
Where in the cell the gene product is active
- endosome
- membrane
- external side of plasma membrane
- cytosol
- interleukin-2 receptor complex
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- coreceptor activity
- interleukin-2 receptor activity
- protein binding
- interleukin-15 receptor activity
- cytokine receptor activity
- interleukin-2 binding