FGF1 Gene Summary [Human]
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009]
Details
| Type | Protein Coding |
| Official Symbol | FGF1 |
| Official Name | fibroblast growth factor 1 [Source:HGNC Symbol;Acc:HGNC:3665] |
| Ensembl ID | ENSG00000113578 |
| Bio databases IDs | |
| Aliases | fibroblast growth factor 1, heparin-binding growth factor 1, endothelial cell growth factor, alpha, endothelial cell growth factor, beta |
| Synonyms | ACIDIC FGF, AFGF, bFGF1, Dffrx, ECGF, ECGFA, ECGFB, ECGF-beta, ECGF-β, EDGF, EDGF II, Fam, FGF, FGF2B, FGFA, FGF-alpha, FGF-α, fibroblast growth factor 1, Fibroblast growth factor alpha, Fibroblast growth factor α, GLIO703, HBGF-1, HEPARIN binding ECGF |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FGF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-trefoil_FGF
- Hsp70 protein binding
- FGF core homology domain
- nuclear export signal
- integrin binding
- fibroblast growth factor receptor binding
- protein binding
- heparin binding
- growth factor
- cysteine rich domain
Pathways
Biological processes and signaling networks where the FGF1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- obesity
- diarrhea
- neoplasia
- neurodegeneration
- primary biliary cirrhosis
- metastatic colorectal cancer
- androgenic alopecia
- hepatic steatosis
- knee osteoarthritis
role in cell
- activation
- production in
- number
- activation in
- proliferation
- expression in
- apoptosis
- survival
- migration
- neurite outgrowth in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- Cytoplasm
- cell surface
- Nucleus
- Plasma Membrane
- cytosol
- nucleoplasm
- nuclear rim
- neurites
- extracellular matrix
- perikaryon
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FGF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of MAP kinase activity
- positive regulation of cell proliferation
- branch elongation involved in ureteric bud branching
- fibroblast growth factor receptor signaling pathway
- anatomical structure morphogenesis
- positive regulation of cholesterol biosynthetic process
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of angiogenesis
- wound healing
- mesonephric epithelium development
- epithelial cell proliferation
- cellular response to heat
- positive regulation of cell division
- angiogenesis
- positive regulation of endothelial cell migration
- activation of protein kinase B activity
- lung development
- signal transduction
- organ morphogenesis
- positive regulation of gene expression
- positive regulation of ERK1 and ERK2 cascade
- organ induction
- cell differentiation
- regulation of endothelial cell chemotaxis to fibroblast growth factor
- regulation of cell migration
- positive regulation of hepatocyte proliferation
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- cytoplasm
- cell cortex
- cytosol
- extracellular matrix
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- integrin binding
- heparin binding
- S100 protein binding
- Hsp70 protein binding
- fibroblast growth factor receptor binding