Lyn Gene Summary [Mouse]
Enables SH3 domain binding activity; non-membrane spanning protein tyrosine kinase activity; and phosphatidylinositol 3-kinase activator activity. Involved in several processes, including cell surface receptor signaling pathway; protein phosphorylation; and regulation of signal transduction. Acts upstream of or within several processes, including B cell receptor signaling pathway; neuroinflammatory response; and regulation of release of sequestered calcium ion into cytosol. Located in several cellular components, including membrane raft; nucleus; and plasma membrane. Part of protein-containing complex. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; liver and biliary system; and nervous system. Used to study systemic lupus erythematosus. Orthologous to human LYN (LYN proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lyn |
| Official Name | LYN proto-oncogene, Src family tyrosine kinase [Source:MGI Symbol;Acc:MGI:96892] |
| Ensembl ID | ENSMUSG00000042228 |
| Bio databases IDs | |
| Aliases | LYN proto-oncogene, Src family tyrosine kinase |
| Synonyms | Hck-2, JTK8, LOC100862590, LYN KINASE, LYN proto-oncogene, Src family tyrosine kinase, p53/56 Lyn, p53Lyn, p53/p56 Lyn, p56Lyn, SAIDV |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lyn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase
- kinase noncatalytic C-lobe domain
- N-terminal tail
- receptor activator
- phosphoprotein binding
- ephrin receptor binding
- phosphoinositide 3-kinase regulator
- protein-tyrosine kinase
- Protein kinase domain
- unique protein domain
- Sh3 domain binding motif
- myristoylation sequence
- ion channel binding
- Src homology 2 (SH2) domain
- Tyrosine kinase, catalytic domain
- SH4 domain
- ubiquitin protein ligase binding
- palmitoylation site
- sphingolipid binding
- Protein kinase (unclassified specificity)
- lipid binding
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- platelet-derived growth factor receptor binding
- enzyme binding
- non-membrane spanning protein tyrosine kinase
- protein binding
- receptor binding
- SH3-domain binding
- Src Homology 3 domain superfamily
- caveolin binding domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- gamma-tubulin binding
- kinase domain
- polybasic membrane localization signal
- binding protein
- Protein Kinases, catalytic domain
- erythropoietin receptor binding
- integrin binding
- tyrosine kinase domain
Pathways
Biological processes and signaling networks where the Lyn gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- B Cell Receptor Signaling
- Circadian Rhythm Signaling
- CTLA4 Signaling in Cytotoxic T Lymphocytes
- CXCR4 Signaling
- Ephrin A Signaling
- Fc Epsilon RI Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- FcγRIIB Signaling in B Lymphocytes
- GM-CSF Signaling
- GP6 Signaling Pathway
- HER-2 Signaling in Breast Cancer
- IL-15 Production
- IL-7 Signaling Pathway
- Opioid Signaling Pathway
- p70S6K Signaling
- Phagosome Formation
- PI3K Signaling in B Lymphocytes
- Reelin Signaling in Neurons
- Role of NFAT in Regulation of the Immune Response
- Role of Tissue Factor in Cancer
- Serotonin Receptor Signaling
- Systemic Lupus Erythematosus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atopic dermatitis
- systemic lupus erythematosus
- hemolytic anemia
- psoriasis
- neoplastic cell transformation
- precursor B-cell acute lymphoblastic leukemia
- metastasis
- neoplasia
- glioma formation
- glomerulosclerosis
phenotypes
- abnormal gait
- abnormal maxilla morphology
- decreased bone mineral content
- decreased circulating bilirubin level
- decreased hemoglobin content
- decreased large unstained cell number
- decreased leukocyte cell number
- decreased lymphocyte cell number
- enlarged spleen
- increased blood urea nitrogen level
- increased monocyte cell number
- increased neutrophil cell number
- increased red blood cell distribution width
- increased spleen weight
- short tibia
- small thymus
- thrombocytopenia
- abnormal B cell activation
- abnormal B cell morphology
- abnormal B cell physiology
- abnormal chemokine level
- abnormal circulating bilirubin level
- abnormal circulating chemokine level
- abnormal circulating complement protein level
- abnormal circulating cytokine level
- abnormal class switch recombination
- abnormal dendritic cell physiology
- abnormal inflammatory response
- abnormal leukocyte cell number
- abnormal level of surface class II molecules
- abnormal lymphocyte cell number
- abnormal macrophage physiology
- abnormal microglial cell physiology
- abnormal monocyte cell number
- abnormal myelopoiesis
- abnormal neutrophil cell number
- abnormal platelet cell number
- abnormal proerythroblast morphology
- abnormal spleen B cell follicle morphology
- abnormal spleen morphology
- abnormal spleen weight
- albuminuria
- anemia
- decreased B cell number
- decreased B cell proliferation
- decreased B-1 B cell number
- decreased IgG level
- decreased IgM level
- decreased T cell number
- decreased follicular B cell number
- decreased marginal zone B cell number
- decreased mature B cell number
- decreased spleen red pulp amount
- decreased spleen weight
- decreased spleen white pulp amount
- decreased transitional stage B cell number
- enlarged lymph nodes
- extramedullary hematopoiesis
- glomerulonephritis
- glomerulosclerosis
- impaired hematopoiesis
- impaired humoral immune response
- increased B cell proliferation
- increased B-1 B cell number
- increased IgA level
- increased IgE level
- increased IgG level
- increased IgG1 level
- increased IgG2b level
- increased IgM level
- increased T cell number
- increased anti-double stranded DNA antibody level
- increased anti-nuclear antigen antibody level
- increased autoantibody level
- increased basophil cell number
- increased circulating interferon-gamma level
- increased circulating interleukin-12 level
- increased circulating interleukin-17 level
- increased circulating interleukin-6 level
- increased circulating total protein level
- increased dendritic cell number
- increased erythroid progenitor cell number
- increased immature B cell number
- increased immunoglobulin level
- increased macrophage cell number
- increased mast cell number
- increased plasma cell number
- increased spleen white pulp amount
- increased susceptibility to systemic lupus erythematosus
- liver inflammation
- mesangial cell interposition
- myeloid hyperplasia
- peritoneal inflammation
- premature death
- renal glomerular immunoglobulin deposits
- renal glomerular protein deposits
- renal glomerulus hypertrophy
- small Peyer's patches
- spleen hyperplasia
- spleen hypoplasia
role in cell
- expression in
- activation in
- proliferation
- growth
- apoptosis
- phosphorylation in
- cell death
- cell viability
- autophagy by
- molecular cleavage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent-insoluble membrane fraction
- microsomal fraction
- plasma membrane fraction
- raft fractions
- detergent-insoluble fractions
- membrane fraction
- detergent resistant lipid raft fraction
- glutaminergic synapse
- endocytic vesicle membrane
- intracellular membrane-bounded organelle
- organelle
- cell periphery
- perinuclear region
- filamentous network
- actin cytoskeleton
- membrane skeleton
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- cytoplasmic face of plasma membrane
- caveolae
- mitochondrial membrane
- mitochondrial inner membrane
- lysosome membrane
- growth cone
- synaptosomes
- membrane rafts
- filopodia
- exosomes
- cell-cell adherens junctions
- detergent-soluble fraction
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lyn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-tyrosine phosphorylation
- C-X-C chemokine receptor CXCR4 signaling pathway
- protein autophosphorylation
- regulation of platelet aggregation
- response to axon injury
- positive regulation of tyrosine phosphorylation of STAT protein
- response to toxin
- hemopoietic progenitor cell differentiation
- positive regulation of Fc receptor mediated stimulatory signaling pathway
- negative regulation of myeloid leukocyte differentiation
- regulation of mast cell degranulation
- regulation of erythrocyte differentiation
- tolerance induction to self antigen
- fatty acid transport
- eosinophil differentiation
- positive regulation of neuron projection development
- positive regulation of oligodendrocyte progenitor proliferation
- JAK-STAT cascade involved in growth hormone signaling pathway
- regulation of monocyte chemotaxis
- negative regulation of toll-like receptor 4 signaling pathway
- toll-like receptor 4 signaling pathway
- adaptive immune response
- response to organic cyclic compound
- response to hormone stimulus
- response to DNA damage stimulus
- DNA damage checkpoint
- erythrocyte differentiation
- immune response-regulating cell surface receptor signaling pathway
- ephrin receptor signaling pathway
- lipopolysaccharide-mediated signaling pathway
- regulation of mast cell activation
- negative regulation of toll-like receptor 2 signaling pathway
- positive regulation of cell migration
- oligodendrocyte development
- negative regulation of MAP kinase activity
- negative regulation of cell proliferation
- positive regulation of cell proliferation
- response to amino acid stimulus
- Fc-epsilon receptor signaling pathway
- Fc-gamma receptor signaling pathway involved in phagocytosis
- response to xenobiotic stimulus
- protein phosphorylation
- stimulatory C-type lectin receptor signaling pathway
- Fc receptor mediated inhibitory signaling pathway
- platelet degranulation
- cellular response to heat
- response to insulin stimulus
- negative regulation of B cell proliferation
- dendritic cell differentiation
- negative regulation of immune response
- regulation of B cell receptor signaling pathway
- negative regulation of mast cell proliferation
- positive regulation of mast cell proliferation
- B cell receptor signaling pathway
- positive regulation of dendritic cell apoptotic process
- T cell costimulation
- interleukin-5-mediated signaling pathway
- neuron projection development
- signal transduction
- positive regulation of glial cell proliferation
- response to carbohydrate stimulus
- transmembrane receptor protein tyrosine kinase signaling pathway
- response to sterol depletion
- positive regulation of MAPK cascade
- Fc receptor mediated stimulatory signaling pathway
- B cell homeostasis
- histamine secretion by mast cell
- negative regulation of inflammatory response to antigenic stimulus
- regulation of release of sequestered calcium ion into cytosol
- regulation of ERK1 and ERK2 cascade
- regulation of cell adhesion mediated by integrin
- cellular response to retinoic acid
- regulation of protein phosphorylation
- negative regulation of protein phosphorylation
- negative regulation of ERK1 and ERK2 cascade
- innate immune response
- regulation of B cell apoptotic process
- positive regulation of protein phosphorylation
- leukocyte migration
- regulation of cytokine production
Cellular Component
Where in the cell the gene product is active
- mitochondrial crista
- Golgi apparatus
- plasma membrane
- lysosomal membrane
- internal side of plasma membrane
- nucleus
- adherens junction
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- cytoplasm
- intracellular membrane-bounded organelle
- membrane raft
- alpha2-beta1 integrin complex
- cytosol
- endocytic vesicle membrane
Molecular Function
What the gene product does at the molecular level
- glycosphingolipid binding
- platelet-derived growth factor receptor binding
- ephrin receptor binding
- gamma-tubulin binding
- integrin binding
- receptor binding
- ion channel binding
- ATP binding
- scaffold protein binding
- protein tyrosine kinase activity
- protein binding
- ubiquitin protein ligase binding
- non-membrane spanning protein tyrosine kinase activity
- phosphoprotein binding
- SH3 domain binding
- kinase activity