PPP1R13B Gene Summary [Human]
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PPP1R13B |
| Official Name | protein phosphatase 1 regulatory subunit 13B [Source:HGNC Symbol;Acc:HGNC:14950] |
| Ensembl ID | ENSG00000088808 |
| Bio databases IDs | |
| Aliases | protein phosphatase 1 regulatory subunit 13B |
| Synonyms | ASPP1, p53BP2-like, p85, protein phosphatase 1 regulatory subunit 13B, protein phosphatase 1, regulatory subunit 13B, Tp53bp2, Trp53bp2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPP1R13B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Family of unknown function (DUF5585)
- polo kinase kinase
- Ankyrin repeats (many copies)
- MAPK-interacting and spindle-stabilising protein-like
- Ubl1_cv_Nsp3_N-like
- phosphatase
- Ankyrin repeats (3 copies)
- protein binding
- Ankyrin repeat
- Src Homology 3 domain superfamily
- ankyrin repeats
- Gametogenetin
Pathways
Biological processes and signaling networks where the PPP1R13B gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- non-insulin-dependent diabetes mellitus
- schizophrenia
- prostate cancer
- COVID-19
- metabolic syndrome X
- insomnia
- prostatic carcinoma
- substance-related disorder
- bipolar disorder
role in cell
- apoptosis
- growth
- expression in
- cell death
- synthesis in
- senescence
- cell cycle progression
- alternative splicing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- Plasma Membrane
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPP1R13B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction by p53 class mediator resulting in induction of apoptosis
- negative regulation of cell cycle
- regulation of apoptotic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- p53 binding
- protein binding