Il22ra2 Gene Summary [Mouse]
Predicted to enable interleukin-22 binding activity and interleukin-22 receptor activity. Acts upstream of or within negative regulation of inflammatory response and regulation of tyrosine phosphorylation of STAT protein. Located in cytosol. Orthologous to human IL22RA2 (interleukin 22 receptor subunit alpha 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il22ra2 |
| Official Name | interleukin 22 receptor, alpha 2 [Source:MGI Symbol;Acc:MGI:2665114] |
| Ensembl ID | ENSMUSG00000039760 |
| Bio databases IDs | |
| Aliases | interleukin 22 receptor, alpha 2 |
| Synonyms | CRF2-10, CRF2-S1, CRF2X, IL-22BP, IL-22R-alpha-2, IL-22R-α-2, interleukin 22 receptor, alpha 2, interleukin 22 receptor subunit alpha 2, interleukin 22 receptor subunit α 2, interleukin 22 receptor, α 2, ZCYTOR16 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Il22ra2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- interleukin-22 binding
- FN3
- protein binding
- Interferon-alpha/beta receptor, fibronectin type III
- interleukin-22 receptor
- Tissue factor
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Il22ra2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Langerhans cell histiocytosis
- psoriasis
- organismal death
- tumorigenesis
- imiquimod-induced psoriasis
- experimental colitis
- multisystem inflammatory syndrome in children
role in cell
- proliferation
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Extracellular Space
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Il22ra2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of inflammatory response
- cytokine-mediated signaling pathway
- regulation of tyrosine phosphorylation of STAT protein
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytosol
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- interleukin-22 binding
- interleukin-22 receptor activity