Mlh3 Gene Summary [Mouse]
Enables centromeric DNA binding activity and chromatin binding activity. Acts upstream of or within meiotic nuclear division; mismatch repair; and protein localization. Located in chiasma; male germ cell nucleus; and synaptonemal complex. Part of mismatch repair complex. Is expressed in brain; early conceptus; ileum; reproductive system; and trigeminal nerve. Human ortholog(s) of this gene implicated in Lynch syndrome; colorectal cancer; endometrial cancer; and hereditary nonpolyposis colorectal cancer type 7. Orthologous to human MLH3 (mutL homolog 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Mlh3 |
| Official Name | mutL homolog 3 [Source:MGI Symbol;Acc:MGI:1353455] |
| Ensembl ID | ENSMUSG00000021245 |
| Bio databases IDs | |
| Aliases | mutL homolog 3 |
| Synonyms | HNPCC7, mutL homolog 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mlh3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MutL C terminal dimerisation domain
- satellite DNA binding
- MutL C terminal dimerization domain
- Histidine kinase-like ATPase domain
- DNA mismatch repair protein, C-terminal domain
- TopoII_MutL_Trans
- chromatin binding
- protein binding
- centromeric DNA binding
- DNA mismatch repair protein MutL
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- epithelial cancer
- ovarian cancer
- hereditary nonpolyposis colorectal cancer type 7
- Lynch syndrome
- epithelial endometrial cancer
- epithelial uterine cancer
- endometrial cancer
- uterine cancer
- pelvic cancer
role in cell
- formation
- DNA damage response
- meiosis I
- meiosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromosome
- nucleoplasm
- synaptonemal complexes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mlh3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- reciprocal meiotic recombination
- male meiosis
- synaptonemal complex assembly
- protein localization
- female meiosis I
- mismatch repair
Cellular Component
Where in the cell the gene product is active
- chiasma
- nucleus
- mismatch repair complex
- synaptonemal complex
- nucleoplasm
- male germ cell nucleus
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- chromatin binding
- mismatched DNA binding
- centromeric DNA binding
- satellite DNA binding