LIPI Gene Summary [Human]
The protein encoded by this gene is a phospholipase that hydrolyzes phosphatidic acid to produce lysophosphatidic acid. Defects in this gene are a cause of susceptibility to familial hypertrigliceridemia. This gene is also expressed at high levels in Ewing family tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Details
| Type | Protein Coding |
| Official Symbol | LIPI |
| Official Name | lipase I [Source:HGNC Symbol;Acc:HGNC:18821] |
| Ensembl ID | ENSG00000188992 |
| Bio databases IDs | |
| Aliases | lipase I, membrane-associated phospholipase A1 beta, cancer/testis antigen 17 |
| Synonyms | CT17, D930038D03Rik, lipase I, lipase, member I, LOC375108, lpd1, LPDL, mPA-PLA1 beta, mPA-PLA1 β, PLA1C, PRED5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LIPI often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alpha/beta hydrolases
- lipase
- enzyme
- heparin binding
- phospholipase
Pathways
Biological processes and signaling networks where the LIPI gene in human plays a role, providing insight into its function and relevance in health or disease.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Plasma Membrane
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LIPI gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid catabolic process
- phosphatidic acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- heparin binding
- carboxylic ester hydrolase activity
- phospholipase activity