Cd22 Gene Summary [Mouse]
Enables CD4 receptor binding activity; protein phosphatase binding activity; and sialic acid binding activity. Involved in several processes, including negative regulation of calcium-mediated signaling; negative regulation of immunoglobulin production; and regulation of B cell proliferation. Located in external side of plasma membrane and neuronal cell body membrane. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; liver and biliary system; and reproductive system. Human ortholog(s) of this gene implicated in diffuse large B-cell lymphoma. Orthologous to human CD22 (CD22 molecule). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd22 |
| Official Name | CD22 antigen [Source:MGI Symbol;Acc:MGI:88322] |
| Ensembl ID | ENSMUSG00000030577 |
| Bio databases IDs | |
| Aliases | CD22 antigen |
| Synonyms | A530093D23, CD22 antigen, Cd22-beta, CD22 molecule, Cd22-β, FLJ22814, Lyb-8, SIGLEC-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cd22 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Immunoglobulin C1-set domain
- immunoglobulin domain
- protein phosphatase binding
- Immunoglobulin I-set domain
- signal peptide
- central domain
- protein binding
- receptor binding
- immunoglobulin binding
- CD4 receptor binding
- T-cell surface glycoprotein CD3 delta chain
- membrane distal domain
- binding protein
- cytoplasmic domain
- immunoreceptor tyrosine-based inhibition motif
- Immunoglobulin like
- sialic acid-binding domain
- immunoglobulin-like protein domain
- transmembrane receptor
- coreceptor
Pathways
Biological processes and signaling networks where the Cd22 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diffuse large B-cell lymphoma
- T acute lymphoblastic leukemia
- precursor B-cell acute lymphoblastic leukemia
- lymphoma
- colorectal cancer
- systemic lupus erythematosus
- overall survival
- contact hypersensitivity
- multiple system atrophy
- acute lymphoblastic leukemia
phenotypes
- decreased lymphocyte cell number
- hydrometra
- increased neutrophil cell number
- small superior vagus ganglion
- abnormal B cell activation
- abnormal B cell differentiation
- abnormal B cell physiology
- abnormal B cell proliferation
- abnormal CD4-positive alpha-beta T cell physiology
- abnormal humoral immune response
- abnormal immune system morphology
- abnormal immune system physiology
- abnormal immunoglobulin level
- abnormal mature B cell morphology
- abnormal peripheral B cell anergy
- abnormal transitional stage B cell morphology
- absent mature B cells
- arrested B cell differentiation
- autoimmune response
- decreased B cell number
- decreased B cell proliferation
- decreased B-2 B cell number
- decreased IgG1 level
- decreased IgG3 level
- decreased IgM level
- decreased cell migration
- decreased marginal zone B cell number
- decreased mature B cell number
- decreased memory B cell number
- decreased transitional stage B cell number
- decreased transitional stage T1 B cell number
- decreased transitional stage T2 B cell number
- increased B cell apoptosis
- increased B cell proliferation
- increased B-1 B cell number
- increased B-1a cell number
- increased CD4-positive CD25-positive alpha-beta regulatory T cell number
- increased CD8-positive alpha-beta memory T cell number
- increased IgG level
- increased IgG1 level
- increased IgG2a level
- increased IgM level
- increased activation-induced B cell apoptosis
- increased anti-double stranded DNA antibody level
- premature death
role in cell
- apoptosis
- expression in
- cell death
- phosphorylation in
- activation
- response
- proliferation
- migration
- formation
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- cell-cell contacts
- plasma membrane extracellular face
- microdomains
- recycling endosomes
- early endosomes
- membrane rafts
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cd22 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of B cell proliferation
- negative regulation of calcium-mediated signaling
- negative regulation of immunoglobulin production
- negative regulation of B cell receptor signaling pathway
- cell adhesion
- regulation of endocytosis
- B cell activation
- regulation of immune response
Cellular Component
Where in the cell the gene product is active
- early endosome
- extracellular vesicular exosome
- cytoplasm
- membrane
- external side of plasma membrane
- neuronal cell body membrane
- recycling endosome
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein phosphatase binding
- protein binding
- CD4 receptor binding
- sialic acid binding
- carbohydrate binding
- IgM binding
- receptor binding