Il17a Gene Summary [Rat]
Predicted to enable cytokine activity; protein heterodimerization activity; and protein homodimerization activity. Involved in cellular response to glucocorticoid stimulus; positive regulation of transcription by RNA polymerase II; and response to amino acid. Located in extracellular space. Used to study anti-basement membrane glomerulonephritis; congestive heart failure; myocarditis; pleurisy; and uveitis. Biomarker of several diseases, including acute necrotizing pancreatitis; inflammatory bowel disease (multiple); lung disease (multiple); myocardial infarction (multiple); and periodontal disease (multiple). Human ortholog(s) of this gene implicated in Mycobacterium avium complex disease; autoimmune disease (multiple); bronchial disease (multiple); macular degeneration; and rhinitis (multiple). Orthologous to human IL17A (interleukin 17A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il17a |
| Official Name | interleukin 17A [Source:RGD Symbol;Acc:2888] |
| Ensembl ID | ENSRNOG00000012467 |
| Bio databases IDs | |
| Aliases | interleukin 17A |
| Synonyms | CTLA-8, cytotoxic T-lymphocyte-associated serine esterase 8, IL-17, ILA17, interleukin 17A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Il17a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein homodimerization
- protein binding
- Interleukin-17
- cytokine
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Il17a gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Airway Inflammation in Asthma
- Airway Pathology in Chronic Obstructive Pulmonary Disease
- Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F
- Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F
- Erythropoietin Signaling
- Hepatic Cholestasis
- HIF1α Signaling
- HMGB1 Signaling
- IL-17 Signaling
- IL-17A Signaling in Airway Cells
- IL-17A Signaling in Fibroblasts
- IL-17A Signaling in Gastric Cells
- RAR Activation
- Role of Cytokines in Mediating Communication between Immune Cells
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of IL-17A in Arthritis
- Role of IL-17A in Psoriasis
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- T Helper Cell Differentiation
- Th17 Activation Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- liver cancer
- cancer
- epithelial cancer
- pancreatic epithelial cancer
- nonalcoholic fatty liver disease
- hyperplasia
- fibrosis
- metastasis
- hepatic steatosis
role in cell
- expression in
- apoptosis
- phosphorylation in
- aggregation
- proliferation
- growth
- accumulation in
- activation in
- adhesion
- outgrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- intracellular space
- plasma membrane extracellular face
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Il17a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of chemokine (C-X-C motif) ligand 1 production
- response to wounding
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of cytokine production involved in inflammatory response
- inflammatory response
- positive regulation of interleukin-23 production
- immune response
- cell death
- positive regulation of osteoclast differentiation
- intestinal epithelial structure maintenance
- apoptotic process
- positive regulation of tumor necrosis factor production
- defense response to fungus
- defense response to Gram-positive bacterium
- keratinocyte proliferation
- defense response to Gram-negative bacterium
- cell-cell signaling
- adaptive immune response
- keratinocyte differentiation
- positive regulation of antimicrobial peptide production
- positive regulation of interleukin-12 production
- Notch signaling pathway
- positive regulation of interleukin-16 production
- innate immune response
- cellular response to interleukin-1
- gene expression
- positive regulation of interleukin-6 production
- positive regulation of interleukin-1 beta production
- fibroblast activation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- external side of plasma membrane
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity
- protein heterodimerization activity
- cytokine activity