Ptprc Gene Summary [Mouse]
Enables several functions, including heparan sulfate proteoglycan binding activity; heparin binding activity; and protein tyrosine phosphatase activity. Involved in several processes, including lymphocyte differentiation; regulation of cytokine production; and regulation of signal transduction. Acts upstream of or within several processes, including T cell activation; positive regulation of lymphocyte activation; and regulation of protein phosphorylation. Located in external side of plasma membrane; focal adhesion; and membrane raft. Is expressed in several structures, including alimentary system; cardiovascular system; hemolymphoid system; placenta; and skin. Used to study Alzheimer's disease and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in multiple sclerosis; severe combined immunodeficiency; and severe combined immunodeficiency 105. Orthologous to human PTPRC (protein tyrosine phosphatase receptor type C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Ptprc |
| Official Name | protein tyrosine phosphatase, receptor type, C [Source:MGI Symbol;Acc:MGI:97810] |
| Ensembl ID | ENSMUSG00000026395 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase, receptor type, C |
| Synonyms | B220, CD45, CD45R, GP180, IMD105, L-CA, loc, LY5, Lyt-4, Ox1, protein tyrosine phosphatase receptor type C, protein tyrosine phosphatase, receptor type, C, RT7, T200 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptprc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein-tyrosine-phoshatase
- wedge domain
- pseudo protein tyrosine phosphatase domain
- Protein tyrosine phosphatase, catalytic domain
- spectrin binding
- protein kinase regulator
- PTP_DSP_cys
- Fibronectin type 3 domain
- tandem repeat
- Protein tyrosine phosphatase, catalytic domain motif
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- Leukocyte receptor CD45
- Protein-tyrosine phosphatase
- ankyrin binding
- cytoplasmic domain
- phosphatase
- intracellular domain
- membrane-proximal domain
- transmembrane receptor
- Protein tyrosine phosphatase N terminal
- extracellular domain
- protein kinase binding
- catalytic domain
- ectodomain
- protein binding
- receptor binding
- phosphatase domain
- acidic domain
- PTPase domain
- binding protein
- FN3
- transmembrane receptor protein tyrosine phosphatase
- protein tyrosine kinase inhibitor activity
- transmembrane domain
- cytosolic tail domain
- heparin binding
Pathways
Biological processes and signaling networks where the Ptprc gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- colorectal cancer
- lymphomagenesis
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
- lymphatic neoplasia
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- lupus nephritis
phenotypes
- CNS inflammation
- abnormal B cell activation
- abnormal B cell differentiation
- abnormal B cell number
- abnormal CD4-positive T cell differentiation
- abnormal CD4-positive alpha-beta intraepithelial T cell morphology
- abnormal CD8-positive alpha beta T cell morphology
- abnormal CD8-positive alpha-beta T cell differentiation
- abnormal NK cell physiology
- abnormal T cell activation
- abnormal T cell differentiation
- abnormal T cell morphology
- abnormal T cell physiology
- abnormal T cell selection
- abnormal T cell subpopulation ratio
- abnormal bone marrow cell morphology/development
- abnormal chemokine secretion
- abnormal cytokine secretion
- abnormal digestion
- abnormal double-positive T cell morphology
- abnormal erythropoiesis
- abnormal follicular B cell physiology
- abnormal granulocyte differentiation
- abnormal humoral immune response
- abnormal immune system cell morphology
- abnormal immune system organ morphology
- abnormal immune system physiology
- abnormal intraepithelial T cell morphology
- abnormal intraepithelial T cell number
- abnormal leukocyte cell number
- abnormal leukocyte morphology
- abnormal long bone metaphysis morphology
- abnormal lymphocyte morphology
- abnormal lymphopoiesis
- abnormal memory T cell number
- abnormal myelination
- abnormal oligodendrocyte morphology
- abnormal osteoclast morphology
- abnormal osteoclast physiology
- abnormal positive T cell selection
- abnormal response to infection
- abnormal thymocyte activation
- absent T cells
- arrested T cell differentiation
- decreased B cell number
- decreased B cell proliferation
- decreased B-1a cell number
- decreased B-1b cell number
- decreased B-2 B cell number
- decreased CD4-positive alpha beta T cell number
- decreased CD4-positive alpha-beta memory T cell number
- decreased CD8-positive alpha-beta T cell number
- decreased CD8-positive alpha-beta memory T cell number
- decreased CD8-positive naive alpha-beta T cell number
- decreased DN4 thymocyte number
- decreased IgE level
- decreased NK T cell number
- decreased NK cell number
- decreased T cell number
- decreased T cell proliferation
- decreased alpha-beta T cell number
- decreased central memory CD8 positive alpha-beta T cell number
- decreased cytotoxic T cell cytolysis
- decreased double-positive T cell number
- decreased effector memory CD4-positive alpha-beta T cell number
- decreased follicular B cell number
- decreased gamma-delta intraepithelial T cell number
- decreased leukocyte cell number
- decreased mast cell degranulation
- decreased mature B cell number
- decreased memory B cell number
- decreased memory T cell number
- decreased oligodendrocyte number
- decreased single-positive T cell number
- decreased susceptibility to type I hypersensitivity reaction
- decreased systemic arterial systolic blood pressure
- decreased thymocyte number
- diarrhea
- enlarged lymph nodes
- enlarged spleen
- extramedullary hematopoiesis
- glomerulonephritis
- increased B cell number
- increased B-1 B cell number
- increased B-1b cell number
- increased CD8-positive alpha-beta T cell number
- increased DN3 thymocyte number
- increased IgA level
- increased IgG2a level
- increased NK cell number
- increased T cell apoptosis
- increased T cell number
- increased alpha-beta T cell number
- increased anti-double stranded DNA antibody level
- increased central memory CD4-positive alpha-beta T cell number
- increased central memory CD8 positive alpha-beta T cell number
- increased dendritic cell number
- increased double-negative T cell number
- increased effector memory CD4-positive alpha-beta T cell number
- increased effector memory CD8-positive alpha-beta T cell number
- increased memory T cell number
- increased neutrophil cell number
- increased plasma cell number
- increased plasmacytoid dendritic cell number
- increased single-positive T cell number
- increased spleen red pulp amount
- increased spleen white pulp amount
- increased susceptibility to Herpesvirales infection
- increased susceptibility to autoimmune disorder
- increased transitional stage B cell number
- increased urine protein level
- kidney failure
- lethality at weaning incomplete penetrance
- liver inflammation
- lung inflammation
- lymph node hyperplasia
- no abnormal phenotype detected
- oliguria
- premature death
- spleen hyperplasia
- thymus hypoplasia
role in cell
- apoptosis
- activation in
- phosphorylation in
- aggregation
- proliferation
- expression in
- cell death
- production in
- survival
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- pH resistant lipid raft fraction
- Cytoplasm
- cell surface
- cell periphery
- intracellular space
- cellular membrane
- focal adhesions
- secretory granule membrane
- cytoplasmic face of plasma membrane
- plasma membrane extracellular face
- microdomains
- plasma membrane projections
- membrane blebs
- membrane rafts
- exosomes
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptprc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of protein tyrosine kinase activity
- positive regulation of Fc receptor mediated stimulatory signaling pathway
- hemopoietic progenitor cell differentiation
- positive regulation of immunoglobulin production
- defense response to virus
- positive regulation of tumor necrosis factor production
- regulation of cell cycle
- release of sequestered calcium ion into cytosol
- response to gamma radiation
- positive regulation of hematopoietic stem cell migration
- negative regulation of protein autophosphorylation
- B cell differentiation
- B cell proliferation
- regulation of JAK-STAT cascade
- positive regulation of T cell proliferation
- positive thymic T cell selection
- T cell differentiation
- positive regulation of protein kinase activity
- positive regulation of stem cell proliferation
- positive regulation of humoral immune response mediated by circulating immunoglobulin
- regulation of gene expression
- positive regulation of B cell proliferation
- negative regulation of T cell mediated cytotoxicity
- positive regulation of T cell mediated cytotoxicity
- positive regulation of phagocytosis
- negative thymic T cell selection
- regulation of phagocytosis
- regulation of interleukin-8 production
- positive regulation of gamma-delta T cell differentiation
- extrinsic apoptotic signaling pathway
- alpha-beta T cell proliferation
- T cell activation
- negative regulation of protein kinase activity
- leukocyte cell-cell adhesion
- bone marrow development
- positive regulation of calcium-mediated signaling
- negative regulation of cytokine-mediated signaling pathway
- MAPK cascade
- negative regulation of interleukin-2 production
- negative regulation of cell adhesion involved in substrate-bound cell migration
- positive regulation of alpha-beta T cell proliferation
- regulation of T cell receptor signaling pathway
- positive regulation of antigen receptor-mediated signaling pathway
- dephosphorylation
- positive regulation of peptidyl-tyrosine phosphorylation
- T cell receptor signaling pathway
- positive regulation of interleukin-2 production
- B cell receptor signaling pathway
- negative regulation of peptidyl-tyrosine phosphorylation
- protein dephosphorylation
- cell surface receptor signaling pathway
- positive regulation of isotype switching to IgG isotypes
- positive regulation of MAPK cascade
- stem cell development
- gamma-delta T cell differentiation
- natural killer cell differentiation
- negative regulation of ERK1 and ERK2 cascade
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of extrinsic apoptotic signaling pathway
- heterotypic cell-cell adhesion
Cellular Component
Where in the cell the gene product is active
- secretory granule membrane
- extracellular vesicular exosome
- focal adhesion
- membrane raft
- membrane
- external side of plasma membrane
- bleb
- synapse
- plasma membrane
- internal side of plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- spectrin binding
- protein tyrosine phosphatase activity
- ankyrin binding
- heparan sulfate proteoglycan binding
- heparin binding
- transmembrane receptor protein tyrosine phosphatase activity
- receptor binding