Nme4 Gene Summary [Rat]
Enables 2,4-dienoyl-CoA reductase (NADPH) activity and trans-2-enoyl-CoA reductase (NADPH) activity. Involved in unsaturated fatty acid biosynthetic process. Predicted to be located in peroxisome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | Nme4 |
| Official Name | NME/NM23 nucleoside diphosphate kinase 4 [Source:RGD Symbol;Acc:1591334] |
| Ensembl ID | ENSRNOG00000050424 |
| Bio databases IDs | |
| Aliases | NME/NM23 nucleoside diphosphate kinase 4 |
| Synonyms | 2,4-dienoyl-CoA reductase 2, 2-4-dienoyl-Coenzyme A reductase 2, peroxisomal, D2, d4-dienoylcoa reductase, Dcrakl, PDCR, putativeperoxisomal24-dienoyl-CoAreductase, SDR17C1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nme4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- polyketide synthase keto reductase domain
- Rossmann-fold NAD(P)(+)-binding proteins
- 2,4-dienoyl-CoA reductase (NADPH2)
- KR domain
- NADP oxidoreductase coenzyme F420-dependent
- pteridine reductase
- enzyme
- protein binding
- Enoyl-(Acyl carrier protein) reductase
- short chain dehydrogenase
- trans-2-enoyl-CoA reductase (NADPH2)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Hodgkin lymphoma
- Hodgkin disease
regulates
- delta3-enoyl-coenzyme A
- delta2-trans,delta4-trans-decadienoyl coenzyme A
- delta2-enoyl coenzyme A
- 2,4,7,10,13,16,19-docosaheptaenoyl-coenzyme A
- polyunsaturated fatty acids
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- peroxisome membrane
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nme4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- unsaturated fatty acid biosynthetic process
- fatty acid beta-oxidation using acyl-CoA oxidase
- fatty acid metabolic process
Cellular Component
Where in the cell the gene product is active
- peroxisomal membrane
- peroxisome
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- trans-2-enoyl-CoA reductase (NADPH) activity
- 2,4-dienoyl-CoA reductase (NADPH) activity