GeneDetails_Summary_Title
The protein encoded by this gene is an interferon and possesses antiviral activity. The encoded protein binds to the interferon alpha/beta receptor but not to the interferon gamma receptor. This intronless gene has several pseudogenes spread throughout the genome. [provided by RefSeq, Nov 2015]
GeneDetails_GeneDetails_Title
| Gene_type | Protein Coding |
| Official_symbol | IFNW1 |
| Official_name | interferon omega 1 [Source:HGNC Symbol;Acc:HGNC:5448] |
| Ensembl_gene_ID | ENSG00000177047 |
| BioDatabase_IDs | |
| Aliases_list | interferon omega 1, IFN-omega 1, interferon omega-1 |
| Synonyms | IFN-OMEGA, IFN-ω, interferon omega 1, interferon ω 1 |
| Species | Human, Homo sapiens |
GeneDetails_ProteinDomains_Title
GeneDetails_ProteinDomains_Description
- hematopoietin/interferon-class (D200-domain) cytokine receptor ligand
- IFab
- protein binding
- cytokine
GeneDetails_Pathways_Title
GeneDetails_Pathways_Description
- Glucocorticoid Receptor Signaling
- IL-12 Signaling and Production in Macrophages
- Retinoic acid Mediated Apoptosis Signaling
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of Lipids/Lipid Rafts in the Pathogenesis of Influenza
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Role of PI3K/AKT Signaling in the Pathogenesis of Influenza
- Role of PKR in Interferon Induction and Antiviral Response
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
GeneDetails_TopFindings_Title
GeneDetails_TopFindings_Description
disease
- colorectal cancer
- psoriasis
- weight loss
role in cell
- phosphorylation in
- expression in
- activation in
- cell death
- production in
- apoptosis
- proliferation
- differentiation
- activation
- maturation
GeneDetails_SubcellularExpressions_Title
GeneDetails_SubcellularExpressions_Description
- Extracellular Space
GeneDetails_GeneOntologyAnnotations_Title
GeneDetails_GeneOntologyAnnotations_Description
Biological Process
geneOntologyAnnotations_BIOLOGICAL_PROCESS_Description
- B cell differentiation
- positive regulation of peptidyl-serine phosphorylation of STAT protein
- B cell proliferation
- adaptive immune response
- response to virus
- T cell activation involved in immune response
- type I interferon-mediated signaling pathway
- natural killer cell activation involved in immune response
- cytokine-mediated signaling pathway
- response to exogenous dsRNA
- humoral immune response
- defense response to virus
- regulation of cell cycle
Cellular Component
geneOntologyAnnotations_CELLULAR_COMPONENT_Description
- extracellular space
Molecular Function
geneOntologyAnnotations_MOLECULAR_FUNCTION_Description
- interferon-alpha/beta receptor binding
- cytokine activity
- cytokine receptor binding