Ccr6 Gene Summary [Mouse]
Enables C-C chemokine binding activity and C-C chemokine receptor activity. Involved in several processes, including T cell differentiation in thymus; isotype switching to IgA isotypes; and positive regulation of flagellated sperm motility involved in capacitation. Located in external side of plasma membrane; sperm plasma membrane; and sperm principal piece. Is expressed in several structures, including central nervous system; gut; immune system; male reproductive gland or organ; and retina. Orthologous to human CCR6 (C-C motif chemokine receptor 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccr6 |
| Official Name | chemokine (C-C motif) receptor 6 [Source:MGI Symbol;Acc:MGI:1333797] |
| Ensembl ID | ENSMUSG00000040899 |
| Bio databases IDs | |
| Aliases | chemokine (C-C motif) receptor 6 |
| Synonyms | BN-1, C-C CKR-6, C-C motif chemokine receptor 6, CD196, CKR-L3, CMKBR6, DCR2, DRY6, GPR29, GPRCY4, KY411, STRL22 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ccr6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- C-C chemokine receptor
- Cholecystokinin A receptor, N-terminal
- signaling receptor activity
- chemokine receptor
- C-C chemokine binding
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Ccr6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- experimental autoimmune encephalomyelitis
- primary biliary cirrhosis
- Huntington disease
- hypersensitivity reaction type I
- non-melanoma skin cancer
- pulmonary emphysema
- hypothyroidism
- hepatic fibrosis
- tuberculoid leprosy
role in cell
- apoptosis
- quantity
- chemotaxis
- activation
- expression in
- migration
- differentiation
- function
- clonal expansion
- abnormal number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- intracellular space
- cellular membrane
- plasma membrane extracellular face
- sperm midpiece
- sperm tail
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ccr6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of sperm motility involved in capacitation
- signal transduction
- cell chemotaxis
- elevation of cytosolic calcium ion concentration
- cellular defense response
- chemotaxis
- leukocyte migration involved in inflammatory response
- immune response
- regulation of T cell migration
- chemokine-mediated signaling pathway
- dendritic cell chemotaxis
- humoral immune response
- positive regulation of dendritic cell chemotaxis
- isotype switching to IgA isotypes
- thymocyte migration
- T cell migration
- lymphocyte migration
- calcium-mediated signaling
Cellular Component
Where in the cell the gene product is active
- sperm midpiece
- external side of plasma membrane
- sperm principal piece
- sperm flagellum
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- C-C chemokine binding
- protein binding
- signaling receptor activity
- C-C chemokine receptor activity
- chemokine receptor activity