Tlx1 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within several processes, including nervous system development; positive regulation of stem cell proliferation; and spleen development. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; branchial arch; ear; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in adult T-cell leukemia/lymphoma. Orthologous to human TLX1 (T cell leukemia homeobox 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tlx1 |
| Official Name | T cell leukemia, homeobox 1 [Source:MGI Symbol;Acc:MGI:98769] |
| Ensembl ID | ENSMUSG00000025215 |
| Bio databases IDs | |
| Aliases | T cell leukemia, homeobox 1 |
| Synonyms | HOX11, RGD1563655, T cell leukaemia homeobox 1, T-cell leukaemia, homeobox 1, T cell leukemia homeobox 1, T-cell leukemia, homeobox 1, TCL3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tlx1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- glycine proline rich domain
- octapeptide domain
- protein binding
- glutamine-rich domain
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lymphatic neoplasia
- lymphomagenesis
- cancer
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
- B cell cancer
- B-cell neoplasia
- metastasis
- tumorigenesis
role in cell
- apoptosis
- quantity
- expression in
- proliferation
- development
- colony formation
- abnormal morphology
- number
- differentiation
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tlx1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- organ development
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity