PAK3
PAK3 Gene Summary
The protein encoded by this gene is a serine-threonine kinase and forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of a non-syndromic form of X-linked intellectual disability. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2017]
Details
| Type | Protein Coding |
| Official Symbol | PAK3 |
| Official Name | p21 (RAC1) activated kinase 3 [Source:HGNC Symbol;Acc:HGNC:8592] |
| Ensembl ID | ENSG00000077264 |
| Bio databases IDs | |
| Aliases | p21 (RAC1) activated kinase 3 |
| Synonyms | ARA,beta-PAK,bPAK,LOC100129569,LOC104968398,MRX30,MRX47,OPHN3,p21 (RAC1) activated kinase 3,PAK3beta,Pak65alpha,Pak65beta,Pak β,Stk4,XLID30,β-PAK |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- p21 binding domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- autoinhibitory protein domain
- Akt phosphorylation site
- Protein tyrosine and serine/threonine kinase
- ATP-binding domain
- enzyme binding
- protein binding
- autophosphorylation site
- Protein kinase domain
- proline rich domain
- Sh3 domain binding motif
- kinase
- MAP kinase kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- amyloid beta binding domain
- Protein Kinases, catalytic domain
- CRIB
- alcohol group acceptor phosphotransferase
- PIX binding domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the PAK3 gene plays a role, providing insight into its function and relevance in health or disease.
- Agrin Interactions at Neuromuscular Junction
- Angiopoietin Signaling
- CCR3 Signaling in Eosinophils
- Cdc42 Signaling
- CXCR4 Signaling
- Ephrin Receptor Signaling
- Epithelial Adherens Junction Signaling
- ErbB Signaling
- G-Protein Coupled Receptor Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- GNRH Signaling
- Integrin Signaling
- Natural Killer Cell Signaling
- PAK Signaling
- Paxillin Signaling
- Rac Signaling
- Regulation of Actin-based Motility by Rho
- Renal Cell Carcinoma Signaling
- Renin-Angiotensin Signaling
- Semaphorin Signaling in Neurons
- Serotonin Receptor Signaling
- TEC Kinase Signaling
- TNFR1 Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- APP
- COMMD2
- ARHGEF7
- YWHAH
- FXR1
- PXN
- RAC1
- CNTNAP2
- PAK1
- H2BC12
disease
- neoplasia
- Alzheimer disease
- pancreatic cancer
- peripheral arterial disease
- X-linked mental retardation type 30
- hereditary disorder
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- mental retardation
regulated by
- nocodazole
- ZNF217
- SMAD4
- KIF26A
- SOD1
- PAK3
- CDC42
- TP53
- RAC1
- KRAS
regulates
- SMAD3
- p38 MAPK
- actin
- TWIST1
- JNK
- APP
- SMAD2
- TNNI3
- PAK3
- MAPK9
role in cell
- proliferation
- formation
- phosphorylation in
- cell spreading
- migration
- expression in
- growth
- quantity
- apoptosis
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- perinuclear region
- Plasma Membrane
- endosomes
- cytosol
- growth cone
- neurites
- perikaryon
- axons
- dendrites
- postsynaptic density
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the PAK3 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- regulation of MAPK cascade
- synapse organization
- protein phosphorylation
- dendritic spine morphogenesis
- stimulatory C-type lectin receptor signaling pathway
- regulation of actin filament polymerization
- MAPK cascade
- regulation of actin cytoskeleton organization
- regulation of axonogenesis
- axonogenesis
- ephrin receptor signaling pathway
- cellular response to organic cyclic compound
- intracellular signal transduction
- dendrite development
CELLULAR COMPONENT
Where in the cell the gene product is active
- postsynaptic density
- cytoplasm
- cytosol
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- ATP binding
- protein binding
- metal ion binding
- MAP kinase kinase activity
- small GTPase binding
- SH3 domain binding
- protein serine/threonine kinase activity