PIK3CA
PIK3CA Gene Summary
Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. A pseudogene of this gene has been defined on chromosome 22. [provided by RefSeq, Apr 2016]
Details
| Type | Protein Coding |
| Official Symbol | PIK3CA |
| Official Name | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [Source:HGNC Symbol;Acc:HGNC:8975] |
| Ensembl ID | ENSG00000121879 |
| Bio databases IDs | |
| Aliases | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
| Synonyms | 6330412C24RIK,caPI3K,CCM4,CLAPO,CLOVE,CWS5,HMH,MCAP,MCM,MCMTC,p110,p110-alpha,P110 α,phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha,phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha,phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit α,phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit α,PI3K,PI3K-alpha,PI3K alpha isoform,PI3KCA,PI3K p100alpha,PI3K p100α,PI3Kp110alpha,PI3K-α,PI3K α isoform,PIK3A,PK3CA |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PI3-kinase family, p85-binding domain
- Phosphatidylinositol 3- and 4-kinase
- catalytic domain
- phosphatidylinositol-4,5-bisphosphate 3-kinase
- helical domain
- protein binding
- PI3-kinase family, ras-binding domain
- prenylation site
- PI3Ka
- kinase
- protein kinase activator
- phosphatidylinositol 3-kinase
- kinase domain
- Phosphoinositide 3-kinase, catalytic domain
- Protein Kinases, catalytic domain
- Ras-binding domain
- C2 domain
Pathways
Biological processes and signaling networks where the PIK3CA gene plays a role, providing insight into its function and relevance in health or disease.
- Angiopoietin Signaling
- Apelin Cardiomyocyte Signaling Pathway
- Cancer Drug Resistance By Drug Efflux
- CCR3 Signaling in Eosinophils
- Clathrin-mediated Endocytosis Signaling
- CNTF Signaling
- CXCR4 Signaling
- Docosahexaenoic Acid (DHA) Signaling
- ErbB Signaling
- ErbB4 Signaling
- Glucocorticoid Receptor Signaling
- Growth Hormone Signaling
- HER-2 Signaling in Breast Cancer
- IL-9 Signaling
- JAK/Stat Signaling
- LPS-stimulated MAPK Signaling
- MSP-RON Signaling Pathway
- Neurotrophin/TRK Signaling
- NGF Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- p53 Signaling
- PDGF Signaling
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Th2 Pathway
- Thyroid Cancer Signaling
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- EGFR
- SH3KBP1
- p85 PIK3R
- PIK3R2
- RAS
- EEF1A1
- PIK3R1
- MAP2K1
- GALNT12
- TRIM24
disease
- metastatic head and neck squamous cell carcinoma
- recurrent head and neck squamous cell carcinoma
- respiratory tract infection
- lung squamous cell carcinoma
- non-small cell lung carcinoma
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
- cancer
regulated by
- PIK3R
- Ca2+
- TNF
- IL1R
- HRAS
- CD274
- TCF4
- camptothecin
- anti-miR-372 inhibitor
- SLC27A5
regulates
- PTGS2
- EGFR
- cyclic AMP
- TP53
- NANOG
- IL6
- JUN
- FASN
- PLAU
- Ca2+
role in cell
- cell death
- apoptosis
- growth
- ruffling
- number
- activation in
- accumulation in
- proliferation
- function
- upregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- perinuclear region
- Plasma Membrane
- membrane compartment
- intercellular junctions
- cell-cell contacts
- cytosol
- microsomal membrane
- filopodia
- plasma
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the PIK3CA gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- regulation of multicellular organism growth
- insulin receptor signaling pathway
- epidermal growth factor receptor signaling pathway
- phosphatidylinositol-3-phosphate biosynthetic process
- phosphatidylinositol phosphorylation
- response to leucine
- endothelial cell migration
- cardiac muscle contraction
- glucose metabolic process
- negative regulation of neuron apoptotic process
- cellular response to insulin stimulus
- positive regulation of smooth muscle cell proliferation
- protein kinase B signaling cascade
- negative regulation of anoikis
- cellular response to glucose stimulus
- angiogenesis
- liver development
- vasculature development
- energy homeostasis
- phosphorylation
- response to muscle stretch
- platelet activation
- cell migration
- positive regulation of TOR signaling cascade
- T cell receptor signaling pathway
- positive regulation of lamellipodium assembly
- negative regulation of fibroblast apoptotic process
- cardiac muscle cell contraction
- response to muscle inactivity
- T cell costimulation
- insulin-like growth factor receptor signaling pathway
- vascular endothelial growth factor signaling pathway
- anoikis
- regulation of cellular respiration
- adipose tissue development
- negative regulation of gene expression
- negative regulation of actin filament depolymerization
- cellular response to hydrostatic pressure
- regulation of protein phosphorylation
- phosphatidylinositol-mediated signaling
- phagocytosis
- negative regulation of macroautophagy
- response to activity
- actin cytoskeleton organization
- positive regulation of protein kinase B signaling cascade
- response to dexamethasone stimulus
- relaxation of cardiac muscle
CELLULAR COMPONENT
Where in the cell the gene product is active
- 1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex
- phosphatidylinositol 3-kinase complex
- perinuclear region of cytoplasm
- 1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex
- cytoplasm
- intercalated disc
- cytosol
- plasma membrane
- lamellipodium
MOLECULAR FUNCTION
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein kinase activator activity
- insulin receptor substrate binding
- phosphatidylinositol-4,5-bisphosphate 3-kinase activity
- protein serine/threonine kinase activity
- 1-phosphatidylinositol-4-phosphate 3-kinase activity
- kinase activity
- 1-phosphatidylinositol-3-kinase activity