MAP3K21
MAP3K21 Gene Summary
Predicted to enable protein homodimerization activity and protein kinase activity. Predicted to be involved in protein autophosphorylation and signal transduction. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | MAP3K21 |
| Official Name | mitogen-activated protein kinase kinase kinase 21 [Source:HGNC Symbol;Acc:HGNC:29798] |
| Ensembl ID | ENSG00000143674 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase kinase kinase 21, mixed lineage kinase 4 |
| Synonyms | BC021891,dJ862P8.3,KIAA1804,mitogen-activated protein kinase kinase kinase 21,mKIAA1804,MLK4,RGD1306091 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- JUN kinase kinase kinase
- protein homodimerization
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the MAP3K21 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- ATG9A
- PLEKHA7
- GIGYF2
- LYN
- YWHAG
- ZBTB21
- TIAM1
- CLTB
- CDK16
- SIPA1L1
disease
- neoplasia
- epithelial cancer
- serous ovarian adenocarcinoma
- serous ovarian cancer
- tumorigenesis
- prostatic carcinoma
- prostate cancer
- dental enamel hypoplasia
regulated by
- alpha-ketoglutaramate
- WNT5A
- CELA3B
regulates
- MAPK8
- NFkB (complex)
- ATM
- IL6
- CXCL8
- TNFSF15
- IL12A
- MAPK1
- CHUK
- VIM
role in cell
- phosphorylation in
- expression in
- apoptosis
- cell viability
- proliferation
- migration
- colony formation by
- sphere formation by
- invasiveness
- damage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the MAP3K21 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- MAPK cascade
- signal transduction
- protein autophosphorylation
- protein phosphorylation
CELLULAR COMPONENT
Where in the cell the gene product is active
- cytoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein homodimerization activity
- JUN kinase kinase kinase activity
- protein kinase activity