PPAR Signaling
The peroxisome proliferator-activated receptor (PPAR) family consists of PPARα, PPARδ, and PPARγ. They act as ligand activated transcriptional regulators. Their ligands include n-3 and n-6 unsaturated fatty acids and their eicosanoid products which makes the PPARs closely linked to intracellular lipid levels. As a consequence they often regulate the expression of genes involved in lipid metabolism.PPARα and -δ are found in a complex with hsp90/hsp90-XAP2 which maintain PPAR in a repressed state...
Pathway Summary
The peroxisome proliferator-activated receptor (PPAR) family consists of PPARα, PPARδ, and PPARγ. They act as ligand activated transcriptional regulators. Their ligands include n-3 and n-6 unsaturated fatty acids and their eicosanoid products which makes the PPARs closely linked to intracellular lipid levels. As a consequence they often regulate the expression of genes involved in lipid metabolism.PPARα and -δ are found in a complex with hsp90/hsp90-XAP2 which maintain PPAR in a repressed state. These proteins dissociate upon binding of ligand to receptor. PPARα, -γ and -δ form heterodimeric complexes with the retinoid X receptor (RXR), bind to PPRE and induce genes that affect fatty acid metabolism, peroxisome proliferation,colon and hepatocarcinogenesis.PPAR function is supressed by cytokines, growth factors and insulin. For example, IL-1 and TNF-alpha suppress PPAR-γ function through NF-κB activated by the TAK1/TAB1/NIK cascade. PPARγ can be inhibited via the ERK pathway in response to growth factors. COUP-TF strongly antagonizes the action of PPARα. Thus PPARs regulate metabolic pathways.
PPAR Signaling Genes list
Explore Genes related to PPAR Signaling
AIParyl hydrocarbon receptor interacting protein CHUKcomponent of inhibitor of nuclear factor kappa B kinase complex CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 CREBBPCREB binding protein ELP1elongator acetyltransferase complex subunit 1 EP300E1A binding protein p300 ERASES cell expressed Ras FOSFos proto-oncogene, AP-1 transcription factor subunit GRB2growth factor receptor bound protein 2 HRASHRas proto-oncogene, GTPase HSP90AA1heat shock protein 90 alpha family class A member 1 HSP90AB1heat shock protein 90 alpha family class B member 1 HSP90B1heat shock protein 90 beta family member 1 IKBKBinhibitor of nuclear factor kappa B kinase subunit beta IKBKEinhibitor of nuclear factor kappa B kinase subunit epsilon IKBKGinhibitor of nuclear factor kappa B kinase regulatory subunit gamma IL18interleukin 18 IL18RAPinterleukin 18 receptor accessory protein IL1Ainterleukin 1 alpha IL1Binterleukin 1 beta IL1F10interleukin 1 family member 10 IL1R1interleukin 1 receptor type 1 IL1R2interleukin 1 receptor type 2 IL1RAPinterleukin 1 receptor accessory protein IL1RAPL1interleukin 1 receptor accessory protein like 1 IL1RAPL2interleukin 1 receptor accessory protein like 2 IL1RL1interleukin 1 receptor like 1 IL1RL2interleukin 1 receptor like 2 IL1RNinterleukin 1 receptor antagonist IL33interleukin 33 IL36Ainterleukin 36 alpha IL36Binterleukin 36 beta IL36Ginterleukin 36 gamma IL36RNinterleukin 36 receptor antagonist IL37interleukin 37 INSinsulin INSRinsulin receptor JUNJun proto-oncogene, AP-1 transcription factor subunit KRASKRAS proto-oncogene, GTPase MAP2K1mitogen-activated protein kinase kinase 1 MAP2K2mitogen-activated protein kinase kinase 2 MAP3K14mitogen-activated protein kinase kinase kinase 14 MAP3K7mitogen-activated protein kinase kinase kinase 7 MAP4K4mitogen-activated protein kinase kinase kinase kinase 4 MAPK1mitogen-activated protein kinase 1 MAPK14mitogen-activated protein kinase 14 MAPK3mitogen-activated protein kinase 3 MED1mediator complex subunit 1 MRASmuscle RAS oncogene homolog NCOA1nuclear receptor coactivator 1 NCOR1nuclear receptor corepressor 1 NCOR2nuclear receptor corepressor 2 NFKB1nuclear factor kappa B subunit 1 NFKB2nuclear factor kappa B subunit 2 NFKBIANFKB inhibitor alpha NFKBIBNFKB inhibitor beta NFKBIDNFKB inhibitor delta NFKBIENFKB inhibitor epsilon NGFRnerve growth factor receptor NR0B2nuclear receptor subfamily 0 group B member 2 NR1H3nuclear receptor subfamily 1 group H member 3 NR2F1nuclear receptor subfamily 2 group F member 1 NRASNRAS proto-oncogene, GTPase NRIP1nuclear receptor interacting protein 1 PDGFAplatelet derived growth factor subunit A PDGFBplatelet derived growth factor subunit B PDGFCplatelet derived growth factor C PDGFDplatelet derived growth factor D PDGFRAplatelet derived growth factor receptor alpha PDGFRBplatelet derived growth factor receptor beta PPARAperoxisome proliferator activated receptor alpha PPARDperoxisome proliferator activated receptor delta PPARGperoxisome proliferator activated receptor gamma PPARGC1APPARG coactivator 1 alpha PTGS2prostaglandin-endoperoxide synthase 2 RAF1Raf-1 proto-oncogene, serine/threonine kinase RALARAS like proto-oncogene A RALBRAS like proto-oncogene B RAP1ARAP1A, member of RAS oncogene family RAP1BRAP1B, member of RAS oncogene family RAP2ARAP2A, member of RAS oncogene family RAP2BRAP2B, member of RAS oncogene family RASD1ras related dexamethasone induced 1 RASD2RASD family member 2 RELREL proto-oncogene, NF-kB subunit RELARELA proto-oncogene, NF-kB subunit RELBRELB proto-oncogene, NF-kB subunit RRASRAS related RRAS2RAS related 2 RXRAretinoid X receptor alpha SCAND1SCAN domain containing 1 SHC1SHC adaptor protein 1 SNW1SNW domain containing 1 SOS1SOS Ras/Rac guanine nucleotide exchange factor 1 SOS2SOS Ras/Rho guanine nucleotide exchange factor 2 SRA1steroid receptor RNA activator 1 STAT5Asignal transducer and activator of transcription 5A STAT5Bsignal transducer and activator of transcription 5B TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1 TNFtumor necrosis factor TNFRSF11BTNF receptor superfamily member 11b TNFRSF1ATNF receptor superfamily member 1A TNFRSF1BTNF receptor superfamily member 1B TRAF2TNF receptor associated factor 2 TRAF6TNF receptor associated factor 6
Products related to PPAR Signaling
Explore products related to PPAR Signaling
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