Target List
Insulin Signaling
AKT1, FOXA2 (HNF3B), FOXO1, GSK3B, IGF1, IGFBP1, INSR, IRS1, MAPK1 (ERK2), MAPK8 (JNK1), MTOR, PIK3CA (p110-alpha), PIK3R1 (p85-ALPHA), PKLR, PPARGC1A (PGC-1α), PRKAA1 (AMPK), PTPN1 (PTP1B), SLC2A4 (GLUT4), SOCS3, SREBF1
Adipokine Signaling
ADIPOR1, ADIPOR2, AKT1, CD36, IRS1, LEPR, MAPK8 (JNK1), MTOR, NFKB1, PPARA, PPARGC1A (PGC-1α), PRKAA1 (AMPK), RXRA, SERPINE1 (PAI-1), SLC2A1, SLC2A4 (GLUT4), SOCS3, STAT3, TNF
Non-Insulin Dependent Diabetes Mellitus
GCK, INSR, IRS1, MAPK1 (ERK2), MAPK8 (JNK1), MTOR, PIK3CA (p110-alpha), PIK3R1 (p85-ALPHA), PKLR, PNPLA3, SLC2A2, SLC2A4 (GLUT4), SOCS3, TNF, XBP1
Metabolic Pathways
Carbohydrate Metabolism
ACLY, G6PC, G6PD, GCK, GSK3B, MLXIPL, PCK2, PDK4, PKLR, RBP4
Beta-Oxidation
ACADL, ACOX1, AKT1, CPT1A, CPT2, FABP1, IRS1, MTOR, PPARA
Cholesterol Metabolism & Transport
ABCA1, APOA1, APOB, APOC3, APOE, CD36, CNBP, CYP2E1, CYP7A1, HMGCR, LDLR, LEPR, NR1H2, NR1H3, NR1H4, PPARA, PPARG, PRKAA1 (AMPK), RXRA, SREBF1, SREBF2
Other Lipid Metabolism & Transport Genes
ACACA, ACSL5, ACSM3, DGAT2, FABP3, FABP5, FASN, GK, HNF4A, LPL, PNPLA3, PPA1, SCD, SLC27A5
Oxidative Phosphorylation
ATP5F1C, NDUFB6, PPA1
Inflammatory Response
CEBPB, FAS, IFNG, IL10, IL1B, IL6, NFKB1, RXRA, TNF
Apoptosis
AKT1, CASP3, CEBPB, FAS, MAPK1 (ERK2), MAPK8 (JNK1), NFKB1, PIK3CA (p110-alpha), PPARG, PRKAA1 (AMPK), RXRA, SERPINE1 (PAI-1), SOCS3, TNF