Target List
JAK & STAT Proteins
Janus Kinase Activity
Jak1, Jak2, Jak3, Tyk2
STAT Family Members
Stat1, Stat2, Stat3, Stat5a, Stat5b, Stat6
JAK / STAT Signaling Regulators
Pias1, Pias2, Prl, Ptpn1 (Ptp), Ptprc (Cd45), Sirpa, Socs1, Socs2, Socs3, Socs4, Socs5
Receptors Binding & Activating JAK Proteins
Csf1r, Cxcl9, Egfr, Epor, Fas, Fcgr1a, Ghr, Ifnar1, Ifngr1, Il10ra, Il10rb, Il2ra (Cd25), Il2rg, Il4r, Il6st (Gp130), Insr, Mpl (Tpor), Nr3c1 (QuantiNova Symbol: AABR07031756.1), Pdgfra, Prlr, Ptprc (Cd45)
SH3 / SH2 Adaptor Protein Activity
Crk, Grb2, Sh2b1, Src, Stam
STAT-Interacting Transcription Factors & Regulators
Transcriptional Factors
Cebpb, Gata3, Hnf4a, Irf1, Jun, Junb, Myc, Nfkb1, Nr3c1 (QuantiNova Symbol: AABR07031756.1), Smad1, Smad2, Smad3, Smad4, Smad5, Sp1, Usf1
Transcriptional Regulation
Yy1
STAT-Induced
STAT1-Induced
Cxcl9, Irf1, Nos2 (Nos2a, iNos)
STAT3-Induced
Bcl2l1 (Bcl-xl), Bcl2l1 (Bcl-xl), Bcl2l1 (Bcl-xl), Ccnd1, Cdkn1a (Cip1, Waf1), Cebpd, Crp, Fas, Irf1, Junb, LOC100911545 (A2m), Lrg1, Myc, Socs1, Socs3
STAT4-Induced
Fcgr1a, Ifng, Irf1, Myc
STAT5-Induced
Bcl2l1 (Bcl-xl), Bcl2l1 (Bcl-xl), Bcl2l1 (Bcl-xl), Ccnd1, Cdkn1a (Cip1, Waf1), Il2ra (Cd25), Irf1, Osm
STAT6-Induced
Fcer2, Gata3, Il4, Il4r
STAT1 / STAT2 / p48 Induced
Isg15
Apoptosis
Akt1, Bcl2l1 (Bcl-xl), Bcl2l1 (Bcl-xl), Bcl2l1 (Bcl-xl), Cdkn1a (Cip1, Waf1), Cebpb, Fas, Ifng, Il4, Jak2, Myc, Nfkb1, Prlr, Spi1
Cell Growth and / or Maintenance
Cell Cycle
Ccnd1, Cdkn1a (Cip1, Waf1), Jun, Junb
Cell Proliferation
Il2ra (Cd25), Jak2, Myc, Ptprc (Cd45), Stat6
Cell Growth
Egfr, Hnf4a, Ifng, Il4, Osm, Pdgfra, Socs1, Socs2, Socs3, Socs4, Socs5
Cell Differentiation
Ccnd1, Cebpb, Gata3, Hnf4a, Il20, Il4, Jak2, Jun, Nos2 (Nos2a, iNos), Prlr, Ptprc (Cd45), Smad2, Socs2, Socs5, Stat3, Stat5a, Stat5b
Immune Response
Acute-Phase Response
Crp, F2 (Thrombin), Stat3
Inflammatory Response
Cebpb, Cxcl9, Ifng, Il20, Il2ra (Cd25), Irf1, Nfkb1, Nos2 (Nos2a, iNos)
Lymphocyte Activation
Ifng, Il4, Prlr
Other Immune Response Genes
Fas, Fcgr1a, Gbp4, Il4r, Il6st (Gp130), Irf9, Isg15, Oas1a, Osm, Ptpn11, Stub1