Target List
Toll-Like Receptor (TLR) Signaling
Toll-Like Receptors & Cofactors
Cd14, Ctsk, Tlr1, Tlr2, Tlr4, Tlr5, Tlr6, Tlr9
MYD88-Dependent
Fadd, Irak1, Irak3, Irf5, Irf7, LOC100910771 (Map3k7), Myd88, Tab1, Tirap, Tlr1, Tlr2, Tlr4, Tlr5, Tlr6, Tlr9, Tollip, Traf6
TICAM1 (TRIF)-Dependent (MYD88-Independent) Signaling
Irf5, Irf7, LOC100910771 (Map3k7), Ripk1, Tab1, Ticam2 (Tram), Tlr4, Traf6
Other Toll-Like Receptor Signaling Genes
Akt1, Casp8 (Flice), Lbp, Pik3ca (p110-alpha), Pik3r1 (PI3KA), Pstpip1, Rac1
NOD-Like Receptor (NLR) Signaling
NOD-Like Receptors
Naip6 (QuantiNova Symbol: AC135826.1), Nlrc4 (Ipaf), Nlrp1a (Nalp1), Nlrp3, Nod2
Inflammasomes
Casp1 (Ice), Naip6 (QuantiNova Symbol: AC135826.1), Nlrc4 (Ipaf), Nlrp1a (Nalp1), Nlrp3, Pycard (Tms1, Asc)
Regulation of NOD-like Receptor (NLR) Signaling
Birc3 (c-IAP1), Card6, Card9, Casp8 (Flice), Hsp90aa1, LOC103694380 (Tnf), Mefv, Ripk2, Sugt1, Xiap
Other Bacterial Pattern Recognition Receptors (PRRs)
Apcs, Crp, Dmbt1 (QuantiNova Symbol: AABR07005821.1), Zbp1
Signaling Downstream of Antibacterial Responses
NFκB Signaling
Bcl10, Chuk (Ikbka, Ikka), Ikbkb (IKK2), Nfkb1, Nfkbia (Iκbα, Mad3), Rela, Tnfrsf1a (Tnfr1)
ERK1 / ERK2 Signaling
Jun, Map2k1 (MEK1), Mapk1 (Erk2), Mapk3 (ERK1)
JNK / p38 Signaling
Jun, Map2k3 (Mek3), Map2k4 (Mkk4, Jnkk1), Mapk14 (p38alpha), Mapk8 (Jnk1)
Apoptosis
Akt1, Birc3 (c-IAP1), Card6, Card9, Casp1 (Ice), Casp8 (Flice), Cd14, Fadd, Ifnb1, Ikbkb (IKK2), Il12a, Il12b, Il1b, Il6, Irak1, Jun, LOC100910771 (Map3k7), LOC103694380 (Tnf), Mapk1 (Erk2), Mapk8 (Jnk1), Mpo, Nfkb1, Nfkbia (Iκbα, Mad3), Pik3ca (p110-alpha), Prdx2, Pycard (Tms1, Asc), Rac1, Ripk1, Ripk2, Tnfrsf1a (Tnfr1), Traf6
Inflammatory Response
Akt1, Apcs, Ccl3 (Mip-1a), Ccl5 (Rantes), Cd14, Crp, Cxcl1, Cxcl3, Il1b, Il6, Lbp, LOC103694380 (Tnf), Lyz2, Mefv, Myd88, Nfkb1, Nlrc4 (Ipaf), Nlrp3, Rac1, Rela, Ripk2, Slc11a1, Ticam2 (Tram), Tirap, Tlr1, Tlr2, Tlr4, Tlr5, Tlr6, Tlr9, Tnfrsf1a (Tnfr1), Tollip
Cytokines & Chemokines
Ccl3 (Mip-1a), Ccl4 (Mip-1b), Ccl5 (Rantes), Cxcl1, Cxcl3, Ifnb1, Il12a, Il12b, Il18, Il1b, Il6
Antimicrobial Peptides
Bpi, Camp, Ctsg, Lcn2 (Ngal), Lyz2, Mpo, Prtn3, Slpi