Target List
Apoptosis
AKT1, BCL2, BCL2L1 (BCLXL), BCL2L1 (BCLXL), BCL2L1 (BCLXL), CASP8 (FLICE), CASP9, FASLG (TNFSF6)
Necrosis
CYLD, GRB2, MAG, PARP2, PVR, TXNL4B
DNA Damage & Repair
ATM, BRCA1, CDKN1A (p21CIP1, WAF1), ERCC2 (XPD), MDM2, RAD51
Mitochondrial Energy Metabolism
ARRDC3, ASB1, CYB561D1, DNAJB1, HSPA1A (HSP70-1A), HSPA1B, SLC25A25
Fatty Acid Metabolism (β-Oxidation)
ACADM, ACADVL, ACOX1, CPT1A, CPT1B, CPT2
Oxidative Stress & Antioxidant Response
AKR1C2, FHL2, GCLM, HMOX1, NCOA7, NQO1, SLC7A11
Heat Shock Response
HSF1 (TCF5), HSP90B1, HSPA4 (HSP70), HSPA8, HSPB1 (HSP27), HSPD1
Endoplasmic Reticulum Stress & Unfolded Protein Response
ADM2, ASNS, DNAJB9, HERPUD1, INHBE, TRIB3 (SKIP3), UHRF1
Cytochrome P450s & Phase I Drug Metabolism
CYP1A2, CYP2B6, CYP2C19, CYP2C9, CYP2D6
Steatosis
CD36, FASN, LPL, PPARA, SCD, SREBF1
Cholestasis
ABCB4, ABCC2 (MRP2, cMOAT), ABCC3 (MRP3, MOAT-D), ATP8B1, SLC51A, PDYN, RDX
Phospholipidosis
ASAH1, HPN, LSS, SERPINA3, SLC2A3, TAGLN, WIPI1
Immunotoxicity
ADH1C, F2 (Thrombin), HPX, LYZ, METAP2, MKI67, NR5A2, TRIM10