Target List
Chemotaxis
Fgf2 (bFGF), Itgb2, Mapk1 (Erk2), Myh10, Myh9, Plaur (uPAR), Pld1, Prkca, Rac2, Tgfb1, Vegfa, Wasf2, Wipf1
Receptors
Egfr, Igf1r, Itga4 (Cd49d), Itgb1, Itgb2, Itgb3, Met, Plaur (uPAR), Rho
Growth Factors
Csf1 (Mcsf), Egf, Fgf2 (bFGF), Hgf, Igf1, Tgfb1, Vegfa
Rho Family GTPases
RHO Signaling
Myl12a (Myl9), Actr2, Actr3, Arhgdia, Limk1, Msn, Mylk, Plcg1, Pld1, Prkca, Pten, Ptpn1 (Ptp1b), Rho, Rhoa, Rhob, Rhoc, Rnd3, Rock1, Vim
RAC Signaling
Actr2, Actr3, Baiap2, Cfl1, Crk, Pak1, Pak4, Pld1, Prkca, Rac1, Rac2, Stat3, Wasf1, Wasf2, Wasl
CDC42 Signaling
Actr2, Actr3, Cdc42, Pfn1, Wasf1, Wasf2, Wasl
Cell Adhesion Molecules
Cell-Cell Adhesion
Dpp4, Egfr, Ezr, Itga4 (Cd49d), Itgb1, Itgb2, Msn, Myh9, Rock1, Tgfb1
Cell-Extracellular Matrix (ECM) Adhesion
Actn1, Actn3, Csf1 (Mcsf), Ilk, Itgb1, Itgb2, Itgb3, Mmp14, Pten, Ptk2b (Pyk2), Pxn, Rasa1, Rhoa
Focal Adhesions
Myl12a (Myl9), Actn1, Actn3, Arhgef7, Bcar1, Capn1, Capn2, Cav1, Enah, Ilk, Itgb1, Ptk2 (Fak), Ptk2b (Pyk2), Pxn, Tln1, Vasp, Vcl
Leukocyte Adhesion & Rolling
Ezr, Itga4 (Cd49d), Itgb1, Itgb2, Msn, Rock1
Integrin Signaling
Bcar1, Ilk, Itga4 (Cd49d), Itgb1, Itgb2, Itgb3, Myh9, Ptk2 (Fak)
Cellular Projections
Filopodia
Baiap2, Cdc42, Diaph1, Egfr, Enah, Ezr, Msn, Rdx, Svil, Vasp
Lamellipodia
Cttn, Dpp4, Egfr, Enah, Fap, Pik3ca (p110alpha), Pld1, Ptk2 (Fak), Pxn, Rdx, Svil, Vasp, Vcl, Wasf1, Wasf2, Wasl
Stress Fibers
Actn4, Diaph1, Myh10, Myh9, Rhoa, Rhob, Rhoc
Membrane Blebs
Actn1, Actn3, Actn4, Ezr, Myh10, Myh9, Mylk, Rnd3, Rock1
Invasive Projections
Actr2, Actr3, Arf6, Cdc42, Cfl1, Cttn, Dpp4, Egf, Ezr, Fap, Mmp14, Mmp2, Mmp9, Msn, Myh9, Plaur (uPAR), Rac2, Sh3pxd2a, Src, Svil, Tgfb1, Vegfa, Wasl, Wipf1
Growth Cones
Arhgef7, Cdc42, Cfl1, Ptk2b (Pyk2)
Membrane Ruffles
Actr2, Actr3, Arf6, Baiap2, Bcar1, Cttn, Diaph1, Ezr, Itgb1, Myh9, Rac1, Rac2, Rasa1, Rdx, Rhoa, Tln1, Wasf2
Cell Polarity
Cdc42, Cfl1, Ezr, Igf1r, Ilk, Myh9
Proteases & Protease Inhibitors
Akt1, Capn1, Capn2, Dpp4, Fap, Hgf, Mmp14, Mmp2, Mmp9, Myh9, Plaur (uPAR), Timp2