Target List
Cancer Stem Cell Markers
Abcb5, Alcam, Aldh1a1 (Raldh1), Atxn1, Bmi1, Cd24a, Cd34, Cd38, Cd44, Eng (Evi-1), Etfa, Flot2, Gata3, Itga2, Itga4 (Cd49d), Itga6, Itgb1, Kit (Cd117), Ms4a1, Muc1 (mucin), Pecam1, Prom1, Ptprc (Cd45), Thy1
Cell Proliferation
Egf, Erbb2 (Her-2, neu), Kitl (Scf), Lin28b, Nos2 (iNos)
Self-Renewal
Bmp7, Dnmt1, Fgfr2
Pluripotency
Klf4, Lin28a, Myc, Nanog, Pou5f1 (Oct4), Sox2
Asymmetric Division
Foxp1, Hdac1, Mycn, Sirt1, Wnt1
Cell Migration & Metastasis
Axl, Id1, Klf17, Plat (tPA), Plaur (uPAR), Snai1 (Snail), Snai2, Twist1, Twist2, Zeb1, Zeb2
Loss of Stemness
Aldh1a1 (Raldh1), Cd34, Dach1, Foxa2 (Hnf3b), Pecam1, Ptch1
Signal Transduction
Hippo Signaling
Lats1, Mertk, Sav1, Taz, Wwc1, Yap1
Hedgehog Signaling
Ptch1, Smo
Notch Signaling
Dll1 (Delta1), Dll4, Jag1, Maml1, Notch1, Notch2
WNT Signaling
Dkk1, Epcam, Fzd7, Wnt1
AKT & PI3 Kinase / mTOR Signaling
Abcg2 (Bcrp), Gsk3b
STAT / NFκB Signaling
Ikbkb (IKKbeta), Jak2, Nfkb1
Cancer Therapeutic Targets
Abcg2 (Bcrp), Atm, Axl, Chek1, Ddr1, Dkk1, Epcam, Fzd7, Gsk3b, Id1, Ikbkb (IKKbeta), Jak2, Klf17, Nfkb1, Ptch1, Smo, Stat3, Tgfbr1 (ALK5), Wee1