Target List
Toll-Like Receptors
Cd180 (Ly78), Tlr1, Tlr2, Tlr3, Tlr4, Tlr5, Tlr6, Tlr7, Tlr9
Pathogen-Specific Responses
Bacterial Response
Ccl2 (Mcp-1), Cd14, Fos, Hmgb1 (QuantiNova Symbol: AABR07035218.1), Hras, Hspa1a (Hsp70-1), Il10, Il12a, Il1b, Il6, Irak1, Jun, Lta (Tnfb), Ly86 (MD-1), Nfkbia (Iκbα, Mad3), Pglyrp1, Ptgs2 (Cox2), Rela, Ripk2, Rnf138 (QuantiNova Symbol: AABR07031480.1), Tlr2, Tlr4, Tlr6, Tnfrsf1a (Tnfr1)
Viral Response
Eif2ak2, Ifnb1, Ifng, Il12a, Il6, Irf3, LOC103694380 (Tnf), Rela, Rnf138 (QuantiNova Symbol: AABR07031480.1), Tbk1, Tlr3, Tlr7
Fungal / Parasitic Response
Hras, Hspa1a (Hsp70-1), Tlr2
Toll-Like Receptor (TLR) Signaling
Negative Regulation of Toll-Like Receptor (TLR) Signaling
Tollip
TICAM1 (TRIF)-Dependent (MYD88-Independent) Signaling
Irf3, LOC100910771 (Map3k7), Nr2c2, Peli1, Rnf138 (QuantiNova Symbol: AABR07031480.1), Tbk1, Ticam2 (Tram), Tlr3, Tlr4, Traf6
MYD88-Dependent Signaling
Irak1, Irak2, LOC100910771 (Map3k7), Myd88, Nr2c2, Tlr1, Tlr2, Tlr4, Tlr5, Tlr6, Tlr7, Tlr9, Traf6
Signaling Downstream of Toll-Like Receptors
NFκB Signaling
Btk, Casp8 (Flice), Chuk (Ikbka, Ikka), Fadd, Ikbkb (IKK2), Il10, Il1b, Il1r1, Irak1, Irak2, Irf3, LOC100910771 (Map3k7), LOC100912618 (Ube2v1), LOC103694380 (Tnf), Ly86 (MD-1), Map3k1 (Mekk1), Map4k4, Nfkb1, Nfkb2, Nfkbia (Iκbα, Mad3), Nfkbib (Trip9), Nfkbil1, Nfrkb, Ppara, Rel, Rela, Tnfrsf1a (Tnfr1), Tnip2, Tradd, Ube2n
JNK / p38 Signaling
Fos, Il1b, Jun, Kcnh8, LOC100910771 (Map3k7), LOC103694380 (Tnf), Map2k3 (Mek3), Map2k4 (Mkk4, Jnkk1), Map3k1 (Mekk1), Mapk8 (Jnk1), Mapk8ip3 (JIP3), Mapk9 (Jnk2)
JAK / STAT Signaling
Ccl2 (Mcp-1), Csf2 (Gm-csf), Csf2 (Gm-csf), Csf2 (Gm-csf), Ifng, Il12a, Il2, Il6
Interferon Regulatory Factor (IRF) Signaling
Cxcl10 (Inp10), Ifna5, Ifnb1, Ifng, Irf1, Irf3, Tbk1
Cytokine Signaling
Ccl2 (Mcp-1), Cebpb, Clec4e, Csf3 (Gcsf), Il1a, Il1b, Il1r1, Il6, Il6r, Irak1, Irak2, LOC103694380 (Tnf), Rela, Tnfrsf1a (Tnfr1)
Regulation of Adaptive Immunity
Cd80, Cd86, Hspd1, Ifng, Il10, Il12a, Il1b, Il2, LOC100910771 (Map3k7), Traf6
Toll-Like Receptor Interacting Proteins & Adaptors
Btk, Cd14, Hmgb1 (QuantiNova Symbol: AABR07035218.1), Hras, Hspa1a (Hsp70-1), Hspd1, Ly86 (MD-1), Mal, Mapk8ip3 (JIP3), Myd88, Peli1, Pglyrp1, Ripk2, Rnf138 (QuantiNova Symbol: AABR07031480.1), Sarm1, Ticam2 (Tram), Tollip
Downstream Effectors of Toll-Like Receptor Signaling
Casp8 (Flice), Eif2ak2, Fadd, Irak1, Irak2, LOC100910771 (Map3k7), LOC100912618 (Ube2v1), Nr2c2, Ppara, Traf6, Ube2n