Target List
Apoptosis
Akt1, Bcl2, Bcl2l1 (Bcl-XL), Bcl2l1 (Bcl-XL), Bcl2l1 (Bcl-XL), Casp8 (Flice), Casp9, Fasl
Necrosis
Cyld, Grb2, Mag, Parp2, Pvr, Txnl4b
DNA Damage & Repair
Atm, Brca1, Cdkn1a (p21Cip1, Waf1), Ercc2 (Xpd), Mdm2, Rad51
Mitochondrial Energy Metabolism
Arrdc3, Asb1, Cyb561d1, Dnajb1, Hspa1a (hsp70A1), Hspa1b, Slc25a25
Fatty Acid Metabolism (β-Oxidation)
Acadm, Acadvl, Acox1, Cpt1a, Cpt1b, Cpt2
Oxidative Stress & Antioxidant Response
Akr1c21, Fhl2, Gclm, Hmox1, Ncoa7, Nqo1, Slc7a11
Heat Shock Response
Hsf1 (Tcf5), Hspa4 (Hsp70), Hspa5 (Grp78), Hspa8, Hspb1 (Hsp27), Hspd1
Endoplasmic Reticulum Stress & Unfolded Protein Response
Adm2, Asns, Dnajb9, Herpud1, Inhbe, Trib3 (Skip3), Uhrf1
Cytochrome P450s & Phase I Drug Metabolism
Cyp1a1, Cyp1a2, Cyp2d22, Cyp2e1, Cyp3a11
Steatosis
Cd36, Fasn, Lpl, Ppara, Scd1, Srebf1
Cholestasis
Abcb4, Abcc2 (Mrp2, cMOAT), Abcc3 (Mrp3, MOAT-D), Atp8b1, Slc51a, Pdyn, Rdx
Phospholipidosis
Asah1, Hpn, Lss, Serpina3n, Slc2a3, Tagln, Wipi1
Immunotoxicity
Adh1, F2 (Thrombin), Hpx, Lyz2, Metap2, Mki67, Nr5a2, Trim10