Target List
Induction of Apoptosis
Death Domain Receptors
CRADD, LOC708606 (FADD), TNFRSF10B (TNFRSF10B, DR5), TNFRSF10B (TNFRSF10B), TNF
DNA Damage & Repair
CIDEA, LOC695164 (TP73), ABL1, TP53 (p53)
Extracellular Apoptotic Signals
CFLAR (CASPER), DAPK1, PRKCA, TNFRSF25 (DR3)
Other Pro-Apoptotic Genes
BAK1, BCL2L11, BNIP1, BNIP3L, CASP1 (ICE), CASP10 (MCH4), CASP14, CASP2, CASP3, CASP4, CASP8 (FLICE), CD27, CD70, DFFA, FAS (TNFRSF6), GADD45A, LOC100426120 (BNIP3), FASLG (TNFSF6), LOC698160 (TRADD), LOC698788 (CASP6), PYCARD (TMS1, ASC), BCL10, BAD, BAX, LTA (TNFB), MAPK1 (ERK2), NOD1, TNFRSF10A (TRAIL-R), TNFRSF9, TNFSF10 (TRAIL), TNFSF8, TP53BP2, TRAF3
Anti-Apoptotic
AKT1, BAG1, BAG3, BAG4, BCL2A1 (Bfl-1, A1), BCL2L10, BDNF, BIRC3 (c-IAP1), BIRC5, BIRC6, BNIP1, BNIP2, BNIP3L, CD27, CD40LG (TNFSF5), CFLAR (CASPER), DAPK1, FAS (TNFRSF6), IGF1R, IL10, IL2, LOC100426120 (BNIP3), LOC693554 (BRAF), BCL2 (BCL2), BCL2L1 (BCL-X), BFAR, BAX, CDKN1A (p21CIP1, WAF1), MCL1, NAIP, NOL3 (CARD6), RIPK2, TNF, XIAP
Regulation of Apoptosis
Negative Regulation of Apoptosis
BAG1, BAG3, BAG4, BCL2A1 (Bfl-1, A1), BCL2L10, BIRC2 (c-IAP1), BIRC3 (c-IAP1), BIRC6, BNIP1, BNIP2, BNIP3L, CASP3, CD27, CD40LG (TNFSF5), CFLAR (CASPER), CIDEA, DAPK1, DFFA, FAS (TNFRSF6), IGF1R, LOC100426120 (BNIP3), LOC693554 (BRAF), LOC695164 (TP73), BCL2 (BCL2), BCL2L1 (BCL-X), BFAR, BCL10, MCL1, NAIP, NOL3 (CARD6), TP53 (p53), XIAP
Positive Regulation of Apoptosis
AKT1, BAK1, BCL2L11, BNIP3L, CASP1 (ICE), CASP10 (MCH4), CASP14, CASP2, CASP4, CASP8 (FLICE), CD40 (TNFRSF5), CD70, CRADD, LOC100426120 (BNIP3), FASLG (TNFSF6), LOC698160 (TRADD), LOC698788 (CASP6), LOC708606 (FADD), PYCARD (TMS1, ASC), TRAF4, TNFRSF10B (TNFRSF10B, DR5), TNFRSF10B (TNFRSF10B), BAD, BAX, ABL1, LTA (TNFB), LTBR, NOD1, RIPK2, TNF, TNFRSF10A (TRAIL-R), TNFRSF25 (DR3), TNFRSF9, TNFSF10 (TRAIL), TNFSF8, TP53 (p53), TP53BP2, TRAF3, TRAF5
Death Domain Receptors
CRADD, DAPK1, LOC698160 (TRADD), LOC708606 (FADD), TNFRSF10B (TNFRSF10B, DR5), TNFRSF10B (TNFRSF10B), TNFRSF10A (TRAIL-R), TNFRSF11B (OPG), TNFRSF1A (TNFR1), TNFRSF21, TNFRSF25 (DR3)
Caspases & Regulators
Caspases
CASP1 (ICE), CASP10 (MCH4), CASP14, CASP2, CASP3, CASP4, CASP5, CASP7, CASP8 (FLICE), CASP9, CFLAR (CASPER), CRADD, LOC698788 (CASP6), PYCARD (TMS1, ASC)
Caspase Activation
APAF1, BCL2L10, CARD8, CASP1 (ICE), CASP9, PYCARD (TMS1, ASC), TNFRSF10B (TNFRSF10B, DR5), TNFRSF10B (TNFRSF10B), BAX, MYC, NOD1, TNFRSF10A (TRAIL-R), TP53 (p53)
Caspase Inhibition
CD27, XIAP