Target List
Autophagy Machinery Components
Autophagic Vacuole Formation
AMBRA1, ATG16L1, ATG4A, ATG4C, ATG4D, ATG5, ATG9A, ATG9B, BECN1, CTSD, GABARAP, GABARAPL2, LAMP1, MAP1LC3B, ATG12 (ATG12), MAP1LC3A, ULK1 (ULK1), GABARAPL1, LOC717813 (ATG4B), LOC718945 (WIPI1), PSEN1, RB1CC1, RGS19, TM9SF1
Vacuole Targeting
ATG4A, ATG4C, ATG4D, GABARAP, LOC717813 (ATG4B)
Protein Transport
ATG16L1, ATG16L2, ATG3, ATG4A, ATG4C, ATG4D, ATG7, ATG9A, GABARAP, GABARAPL2, LOC711835 (ATG10), LOC717813 (ATG4B), RAB24
Autophagosome-Lysosome Linkage
DRAM1, GABARAP, NPC1
Ubiquitination
ATG7, ATG3, PARK7
Proteases
ATG4A, ATG4C, ATG4D, LOC717813 (ATG4B)
Regulation of Autophagy
Co-Regulators of Autophagy & Apoptosis
AKT1, APP, ATG5, BCL2L1 (BCL-X), BAD, BAK1, BAX, BECN1, CASP3, CASP8 (FLICE), CDKN1B, CLN3, CTSB, CXCR4, DAP, DAPK1, DRAM1, EIF2AK3, FAS (TNFRSF6), IFNG, IGF1, LOC100426120 (BNIP3), LOC694767 (HDAC1), ATG12 (ATG12), BCL2 (BCL2), LOC708606 (FADD), HDAC6, MAPK8 (JNK1), NFKB1, PIK3CG, PRKAA1 (AMPK), PTEN, SNCA, SQSTM1, TGFB1, TGM2, TNF, TNFSF10 (TRAIL), TP53 (p53)
Co-Regulators of Autophagy & the Cell Cycle
BAX, CDKN1B, IFNG, MAPT, PTEN, RB1, TGFB1, TP53 (p53)
Autophagy Induction by Intracellular Pathogens
EIF2AK3, IFNG, TLR9
Autophagy in Response to Other Intracellular Signals
EIF4G1, ESR1 (ERα), GAA, HGS, CTSS (CTSS), LOC718976 (MAPK14, p38ALPHA), LOC718976 (MAPK14, p38ALPHA), PIK3CB, PIK3C3, PIK3R4, RPS6KB1, TMEM74, ULK2, UVRAG
Chaperone-Mediated Autophagy
LOC695913 (HSP90AA1)