Target List
Necrosis
Regulation of Necrosis
FAS (TNFRSF6), FASLG (TNFSF6), RIPK1, SLC25A4, TNF
TNF-Induced Necrosis
ATP6V1G2, CYLD, DPYSL4, EIF5B, FOXI1, GALNT5, TMEM57, GRB2 (GRB2), LOC704611 (JPH3), BMF, DENND4A, LOC712324 (COMMD4), HSPBAP1, CCDC103, MAG, PARP2, PVR, RAB25, DEFB1, SPATA2, SYCP2, TXNL4B
Other Necrosis Genes
AR, CA9, CD40 (TNFRSF5), H2AFX, RIPK1, LOC708606 (FADD), RIPK3, LOC721111 (PALM), MPG, MGEA5, PARP1 (ADPRT1), SP1, TMEM123
Potential Necrosis Genes
RIPK1 Interactors
RIPK3, NFKB1, RIPK2
RIPK3 Interactors
GLUD1, GLUL, RIPK1, PYGL
PARP1 Interactors
CAPN1, CAPN2, CAPN3, CAPN7, LOC698077 (CAPN5), LOC699341 (CAPNS1), CAPN6
Death Domain Receptors
FAS (TNFRSF6), TNFRSF1A (TNFR1), TNFRSF10A (TRAIL-R)
Death Receptor Signaling
BIRC3 (c-IAP1), CASP8AP2, CYLD, FAF1, FEM1B, NGFRAP1, LOC698160 (TRADD), LRDD, IKBKG, TNFSF15, RIPK1, LOC708606 (FADD), LOC711681 (NGF), MADD, MYD88, NGFR, PARP1 (ADPRT1), TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1B, TNFRSF25 (DR3), TNFRSF4 (OX40), TNFRSF8, TRAF5
Apoptosis
Pro-Apoptotic
AIFM1, BNIP3L, CASP8AP2, FAF1, FAS (TNFRSF6), FEM1B, NGFRAP1, FASLG (TNFSF6), LOC698160 (TRADD), LRDD, IKBKG, BMF, RIPK1, LOC708606 (FADD), MADD, RIPK3, BAX, LOC100426120 (BNIP3), NGFR, RIPK2, TNFRSF10A (TRAIL-R), TNFRSF25 (DR3), TNFRSF8, TNFSF10 (TRAIL), TRAF5
Anti-Apoptotic
BIRC3 (c-IAP1), FAS (TNFRSF6), RIPK1, LOC711681 (NGF), MYD88, NFKB1, NGFR, RIPK2, TNF, TNFRSF1A (TNFR1), TNFRSF1B, TNFRSF4 (OX40), TRAF5
TNF-Induced Apoptosis
ATP6V1G2, CYLD, SPATA2, SYCP2
Oxidative Stress
AIFM1, GLUD1, CYBB, LOC696748 (CYBA), NOX1, NOX4
Mitochondrial Genes
AIFM1, BNIP3L, GLUD1, GLUL, CYBB, LOC696748 (CYBA), RIPK1, BAX, SLC25A4