Target List
Induction of Apoptosis
Death Domain Receptors
TNF, TNFRSF11B, TNFRSF1A, TNFRSF1B
DNA Damage & Repair
ABL1, CIDEA, CIDEB, TP53 (p53)
Extracellular Apoptotic Signals
LOC100516103
Other Pro-Apoptotic Genes
AIFM3, BAD, BAK1, BAX, BID, BNIP3L, CASP1, CASP10, CASP14, CASP2, CASP3, LOC100522887, CASP6, CASP8 (FLICE), CD40, CD70 (TNFRSF7), CYCS, CUL2, DFFA, DDX20, DPF2, DIABLO, ERN2, FAS (TNFRSF6), FASLG (TNFSF6), FEM1B, GADD45A, HRK, LTA (TNFB), LTBR, LALBA, NOD1, LOC100522011, PPP2R1A, PPP2R1B, SART1, LOC100517325, TNFSF10 (TRAIL), TP53BP2, TRAF2
Anti-Apoptotic
AKT1, BAG3, BAX, BCL2, BCL2A1, BCL2L1 (BCL-X, BCLXL), BCL2L10, LOC100154044, BRAF, LOC100622859, BIRC3, BIRC5, BNIP2, BNIP3L, CBX4, BNIP3, CD40LG (TNFSF5), CFDP1, LOC100516103, ERC1, FAS (TNFRSF6), HRK, IGF1R, IL10, MCL1, MTL5, NFKB1, LOC100523672, RIPK2, PAK7, STAMBP, TNF, XIAP
Death Domain Receptors
LOC100516103, TNFRSF21, TNFRSF11B, TNFRSF1A, TNFRSF1B
Caspases & Regulators
Caspases
CASP1, CASP10, CASP14, CASP2, CASP3, LOC100522887, CASP6, CASP8 (FLICE), LOC100156777 (CASP7), CASP9, LOC641352 (Caspase 15), LOC100522011
Caspase Activation
AIFM1, AIFM3, APAF1, BAX, BCL2L10, CASP1, NOD1, LOC100522011, TP53 (p53)
Caspase Inhibition
XIAP
Other Regulators of Apoptosis
PROP1, RFWD2