Fgr Gene Summary [Mouse]
Enables several functions, including immunoglobulin receptor binding activity; non-membrane spanning protein tyrosine kinase activity; and phosphotyrosine residue binding activity. Involved in several processes, including integrin-mediated signaling pathway; negative regulation of natural killer cell activation; and regulation of vesicle-mediated transport. Acts upstream of or within bone mineralization and skeletal system morphogenesis. Located in plasma membrane. Colocalizes with actin cytoskeleton and ruffle membrane. Is expressed in 2-cell stage embryo; blastocyst; metanephros; nervous system; and neural ectoderm. Orthologous to human FGR (FGR proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fgr |
| Official Name | FGR proto-oncogene, Src family tyrosine kinase [Source:MGI Symbol;Acc:MGI:95527] |
| Ensembl ID | ENSMUSG00000028874 |
| Bio databases IDs | |
| Aliases | FGR proto-oncogene, Src family tyrosine kinase |
| Synonyms | Ali18, C-fgr, c-src2, FGR proto-oncogene, Src family tyrosine kinase, Mhdaali18, p55c-fgr, p55-Fgr, p58c-fgr, p58-Fgr, SRC2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fgr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SH4 domain
- Protein kinase (unclassified specificity)
- protein kinase binding
- Protein tyrosine and serine/threonine kinase
- non-membrane spanning protein tyrosine kinase
- phosphotyrosine binding
- protein binding
- receptor binding
- protein-tyrosine kinase
- Protein kinase domain
- Sh3 domain binding motif
- Src Homology 3 domain superfamily
- kinase
- Serine/Threonine protein kinases, catalytic domain
- binding protein
- Protein Kinases, catalytic domain
- Src homology 2 (SH2) domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Fgr gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Circadian Rhythm Signaling
- CTLA4 Signaling in Cytotoxic T Lymphocytes
- Ephrin A Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- HER-2 Signaling in Breast Cancer
- IL-15 Production
- Opioid Signaling Pathway
- Phagosome Formation
- Reelin Signaling in Neurons
- Role of Tissue Factor in Cancer
- Serotonin Receptor Signaling
- Sperm Motility
- Tec Kinase Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- metastatic colorectal cancer
- systemic lupus erythematosus
- neoplasia
- lymphomagenesis
- Alzheimer disease
- neoplastic cell transformation
- myeloid leukemia
- atopic dermatitis
- lymphoma
role in cell
- formation
- apoptosis
- survival
- cell viability
- production in
- expression in
- cytotoxicity
- phosphorylation in
- activation in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- aggresome
- secretory granule lumen
- cytoskeleton
- Cytoplasm
- Extracellular Space
- actin cytoskeleton
- Plasma Membrane
- cytosol
- membrane ruffles
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fgr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- peptidyl-tyrosine phosphorylation
- positive regulation of mast cell degranulation
- protein autophosphorylation
- Fc-gamma receptor signaling pathway involved in phagocytosis
- protein phosphorylation
- response to virus
- integrin-mediated signaling pathway
- defense response to Gram-positive bacterium
- regulation of protein kinase activity
- bone mineralization
- transmembrane receptor protein tyrosine kinase signaling pathway
- skeletal system morphogenesis
- negative regulation of inflammatory response to antigenic stimulus
- negative regulation of natural killer cell activation
- immune response-regulating cell surface receptor signaling pathway
- innate immune response
- regulation of innate immune response
- myoblast proliferation
- cell differentiation
- positive regulation of cytokine production
- regulation of phagocytosis
- positive regulation of protein kinase B signaling cascade
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- mitochondrial intermembrane space
- extracellular vesicular exosome
- cytoskeleton
- actin cytoskeleton
- ruffle membrane
- cytosol
- secretory granule lumen
- extracellular region
- aggresome
- plasma membrane
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- phosphotyrosine binding
- protein kinase binding
- ATP binding
- protein tyrosine kinase activity
- protein binding
- non-membrane spanning protein tyrosine kinase activity
- Fc-gamma receptor I complex binding
- receptor binding
- immunoglobulin receptor binding