Itga1 Gene Summary [Mouse]
Predicted to enable cell adhesion molecule binding activity; phosphatase activator activity; and protein phosphatase binding activity. Involved in negative regulation of epidermal growth factor receptor signaling pathway. Acts upstream of or within cell adhesion; cellular extravasation; and neutrophil chemotaxis. Located in basal part of cell and external side of plasma membrane. Is expressed in blood vessel endothelium; embryo mesenchyme; intestine smooth muscle; and lung. Used to study type 1 diabetes mellitus. Orthologous to human ITGA1 (integrin subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Itga1 |
| Official Name | integrin alpha 1 [Source:MGI Symbol;Acc:MGI:96599] |
| Ensembl ID | ENSMUSG00000042284 |
| Bio databases IDs | |
| Aliases | integrin alpha 1 |
| Synonyms | alpha1 INTEGRIN, CD49A, E130012M19RIK, integrin alpha 1, integrin subunit alpha 1, integrin subunit α 1, Integrin α-1, VLA1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Itga1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- von Willebrand factor (vWF) type A domain
- cell adhesion molecule binding
- protein phosphatase binding
- extracellular membrane-proximal domain
- von Willebrand factor type A domain
- inserted domain
- protein binding
- receptor binding
- alpha1 domain
- FG-GAP-like repeat
- Integrin alpha (beta-propellor repeats)
- Integrin alpha
- cytoplasmic domain
- vWFA
- transmembrane domain
- intracellular domain
- collagen binding
- VWFA-related Acidobacterial domain
- phosphatase activator
- cytosolic tail domain
- membrane-proximal domain
- FG-GAP repeat
Pathways
Biological processes and signaling networks where the Itga1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Actin Nucleation by ARP-WASP Complex
- Caveolar-mediated Endocytosis Signaling
- Cdc42 Signaling
- Ephrin Receptor Signaling
- ERK/MAPK Signaling
- HGF Signaling
- Integrin Signaling
- Molecular Mechanisms of Cancer
- Osteoarthritis Pathway
- PAK Signaling
- Paxillin Signaling
- PI3K/AKT Signaling
- PTEN Signaling
- Rac Signaling
- Regulation of Actin-based Motility by Rho
- Regulation of Cellular Mechanics by Calpain Protease
- Regulation of eIF4 and p70S6K Signaling
- RhoGDI Signaling
- Sertoli Cell-Sertoli Cell Junction Signaling
- Signaling by Rho Family GTPases
- Tec Kinase Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-insulin-dependent diabetes mellitus
- colitis
- plaque psoriasis
- metastasis
- hyperalbuminemia
- endometriosis
- coronary artery disease
- chronic obstructive pulmonary disease
- mesangiolysis
role in cell
- apoptosis
- production in
- quantity
- proliferation
- expression in
- activation in
- phosphorylation in
- formation
- adhesion
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cell surface
- cell borders
- basal compartment
- cellular membrane
- focal adhesions
- membrane ruffles
- plasma membrane extracellular face
- acrosome
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Itga1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- negative regulation of cell proliferation
- neuron projection morphogenesis
- positive regulation of MAPK cascade
- vasodilation
- negative regulation of epidermal growth factor receptor signaling pathway
- positive regulation of neuron apoptotic process
- integrin-mediated signaling pathway
- cell adhesion mediated by integrin
- positive regulation of phosphoprotein phosphatase activity
- cellular extravasation
- neutrophil chemotaxis
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- focal adhesion
- basal part of cell
- acrosomal vesicle
- membrane
- external side of plasma membrane
- alpha1-beta1 integrin complex
- perikaryon
- integrin complex
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein phosphatase binding
- collagen binding
- metal ion binding
- integrin binding