FSTL1 Gene Summary [Human]
This gene encodes a protein with similarity to follistatin, an activin-binding protein. It contains an FS module, a follistatin-like sequence containing 10 conserved cysteine residues. This gene product is thought to be an autoantigen associated with rheumatoid arthritis. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | FSTL1 |
| Official Name | follistatin like 1 [Source:HGNC Symbol;Acc:HGNC:3972] |
| Ensembl ID | ENSG00000163430 |
| Bio databases IDs | |
| Aliases | follistatin like 1 |
| Synonyms | Follistatin-like, follistatin-like 1, FRP, FSL1, FSTL, MIR198, OCC-1, TSC-36 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FSTL1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EFh_SPARC_EC
- EF-hand domain pair
- EFh
- protein binding
- KAZAL_FS
- heparin binding
- Follistatin/Osteonectin-like EGF domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- bacterial sepsis
- gastric cancer
- airway hyperresponsiveness
- myocardial infarction
- neoplasia
- hepatic fibrosis
- hepatic steatosis
- age-related macular degeneration
- arthritis
role in cell
- expression in
- production in
- migration
- phosphorylation in
- apoptosis
- differentiation
- activation in
- proliferation
- maturation
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Plasma Membrane
- vesicles
- endoplasmic reticulum lumen
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FSTL1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organismal development
- negative regulation of apoptotic process
- cell differentiation
- endothelial cell differentiation
- endothelial cell migration
- regulation of BMP signaling pathway
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- extracellular vesicular exosome
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- heparin binding